Detailed information of TA system TA123058

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 6655..7220
• Replicon: plasmid unnamed
• Accession: NZ_CP038514
• Organism: Aeromonas sp. 2692-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E5E97_RS23360
• Protein ID: WP_128318412.1
• Coordinates: 6655..6945 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E5E97_RS23365
• Protein ID: WP_128318411.1
• Coordinates: 6933..7220 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5E97_RS23335	1766..1999	-	234	WP_128318414.1	hypothetical protein	-
E5E97_RS23340	3197..3544	-	348	Protein_4	transposase	-
E5E97_RS23345	4362..4832	+	471	WP_171281262.1	hypothetical protein	-
E5E97_RS23350	4868..5890	+	1023	WP_171281263.1	methyl-accepting chemotaxis protein	-
E5E97_RS23355	5999..6253	+	255	WP_171281264.1	hypothetical protein	-
E5E97_RS23360	6655..6945	-	291	WP_128318412.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5E97_RS23365	6933..7220	-	288	WP_128318411.1	CopG family ribbon-helix-helix protein	Antitoxin
E5E97_RS23370	7403..7636	-	234	WP_128318410.1	hypothetical protein	-
E5E97_RS23375	7633..8262	-	630	WP_128318409.1	AAA family ATPase	-
E5E97_RS23380	8441..8683	+	243	WP_068979438.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
E5E97_RS23385	8673..8959	+	287	Protein_13	type II toxin-antitoxin system RelE/ParE family toxin	-
E5E97_RS23390	9176..10159	+	984	WP_171281265.1	replication initiation protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..10348	10348

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10881.70 Da
• Isoelectric Point: 10.6871

>T123058 WP_128318412.1 NZ_CP038514:c6945-6655 [Aeromonas sp. 2692-1]
MPPVIFAPAALRDLQRLREFLRPKSQLVAQRAATTIQLSLRQLAAQPSMGRPIEGLPEAFREWVIPFGDSGYLARYRIEP
DVIVVLAVRHQREAGY

Nucleotide

• Length: 291 bp

>T123058 NZ_CP038514:c6945-6655 [Aeromonas sp. 2692-1]
ATGCCACCAGTGATCTTTGCCCCTGCCGCCCTGCGAGACCTGCAACGCCTACGTGAATTCCTGCGCCCTAAGAGCCAGCT
GGTCGCACAGAGGGCCGCAACAACAATCCAATTGTCCCTACGCCAGCTCGCAGCCCAACCTTCTATGGGTCGCCCCATTG
AAGGACTGCCAGAGGCATTTCGTGAGTGGGTGATCCCCTTTGGCGACAGCGGCTATTTAGCCCGCTATCGCATTGAACCG
GATGTCATCGTGGTGCTCGCTGTCCGCCATCAACGCGAAGCAGGCTACTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11105.24 Da
• Isoelectric Point: 4.9049

>AT123058 WP_128318411.1 NZ_CP038514:c7220-6933 [Aeromonas sp. 2692-1]
MPTQSKPVSIKLDADTQERIKRLATSRERSAHWLMREAISQYVEREELRETFHRDTLEAWQEFQETGRYATAQDVDQWLT
SWGTDAEGAPPACHQ

Nucleotide

• Length: 288 bp

>AT123058 NZ_CP038514:c7220-6933 [Aeromonas sp. 2692-1]
ATGCCCACACAATCCAAACCGGTCTCGATCAAACTCGACGCAGACACCCAGGAACGCATCAAACGCCTGGCAACTTCCCG
CGAACGCTCAGCCCACTGGCTCATGCGCGAAGCCATCAGCCAGTATGTCGAGCGCGAAGAACTGCGCGAGACCTTCCACC
GCGACACTCTGGAGGCCTGGCAGGAGTTCCAGGAGACTGGCCGCTATGCCACCGCTCAAGATGTGGATCAGTGGCTAACC
TCTTGGGGCACTGATGCCGAAGGAGCGCCTCCGGCATGCCACCAGTGA