Detailed information of TA system TA123024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2122137..2122620
• Replicon: chromosome
• Accession: NZ_CP038504
• Organism: Corynebacterium diphtheriae strain TH1526

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6J4WN23
• Locus tag: E4651_RS10085
• Protein ID: WP_014307502.1
• Coordinates: 2122137..2122406 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: E4651_RS10090
• Protein ID: WP_014304050.1
• Coordinates: 2122387..2122620 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4651_RS10065	2117382..2118098	-	717	WP_070799449.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
E4651_RS10070	2118151..2119176	-	1026	WP_014307499.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
E4651_RS10075	2119198..2119512	-	315	WP_014307500.1	ATP-binding cassette domain-containing protein	-
E4651_RS10080	2119982..2121801	+	1820	Protein_1914	N-acetylmuramoyl-L-alanine amidase	-
E4651_RS10085	2122137..2122406	-	270	WP_014307502.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4651_RS10090	2122387..2122620	-	234	WP_014304050.1	ribbon-helix-helix protein, CopG family	Antitoxin
E4651_RS12370	2122704..2122916	-	213	WP_082257705.1	hypothetical protein	-
E4651_RS10095	2123347..2123945	-	599	Protein_1918	RloB domain-containing protein	-
E4651_RS10100	2123973..2125304	-	1332	WP_082257706.1	ATP-binding protein	-
E4651_RS10105	2125399..2125977	-	579	WP_014311015.1	restriction endonuclease subunit S	-
E4651_RS10110	2126360..2126620	-	261	WP_014304055.1	hypothetical protein	-
E4651_RS10115	2126727..2127524	-	798	WP_085061425.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10338.92 Da
• Isoelectric Point: 10.6099

>T123024 WP_014307502.1 NZ_CP038504:c2122406-2122137 [Corynebacterium diphtheriae]
VTSWTIEFSPRAAKELRKLDRPVQKRIVAYLREISTLPNPQMRGKALTGNWAGFWRWRVGDYRLVAAIEDDRVVIVVVSI
GHRSQVYED

Nucleotide

• Length: 270 bp

>T123024 NZ_CP038504:c2122406-2122137 [Corynebacterium diphtheriae]
GTGACCTCTTGGACGATTGAGTTTTCTCCACGTGCTGCTAAAGAGCTCCGGAAGCTTGACCGGCCAGTTCAAAAGCGCAT
TGTTGCGTATCTTCGAGAAATTTCTACTCTGCCCAATCCGCAAATGCGTGGTAAGGCGTTAACTGGCAACTGGGCAGGTT
TTTGGCGTTGGCGTGTGGGGGATTACCGCCTCGTTGCAGCTATTGAAGATGATCGTGTTGTCATCGTTGTTGTTTCCATT
GGTCACCGATCTCAGGTTTACGAGGACTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8975.96 Da
• Isoelectric Point: 4.3904

>AT123024 WP_014304050.1 NZ_CP038504:c2122620-2122387 [Corynebacterium diphtheriae]
MSNPVISLRIGASEKERLDELSRRTGRSGSFYIREALEKHLDELEYVYGVRSEYEAIRRGELETISLDEVERDLLDD

Nucleotide

• Length: 234 bp

>AT123024 NZ_CP038504:c2122620-2122387 [Corynebacterium diphtheriae]
ATGAGCAATCCTGTTATTAGCCTACGTATCGGGGCGAGTGAAAAAGAGCGGCTTGATGAGCTATCACGGCGTACCGGCCG
GTCAGGATCTTTTTACATACGAGAAGCCTTAGAAAAACATCTTGACGAGCTTGAGTACGTCTATGGCGTTCGCAGCGAGT
ACGAAGCTATCCGACGCGGAGAGCTAGAGACAATCAGCTTGGACGAGGTAGAGCGTGACCTCTTGGACGATTGA

Structures

Toxin

• AlphaFold DB: A0A6J4WN23