Detailed information of TA system TA123023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/Fic-DUF4065
• Location: 610724..611754
• Replicon: chromosome
• Accession: NZ_CP038504
• Organism: Corynebacterium diphtheriae strain TH1526

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: E4651_RS03055
• Protein ID: WP_014303124.1
• Coordinates: 610724..611176 (-)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: E4651_RS03060
• Protein ID: WP_082257486.1
• Coordinates: 611188..611754 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4651_RS03030	607381..608235	+	855	WP_082257485.1	hypothetical protein	-
E4651_RS03035	608228..609136	-	909	WP_021335602.1	DUF1906 domain-containing protein	-
E4651_RS03040	609265..610464	-	1200	WP_010934563.1	cation:proton antiporter	-
E4651_RS03055	610724..611176	-	453	WP_014303124.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
E4651_RS03060	611188..611754	-	567	WP_082257486.1	SocA family protein	Antitoxin
E4651_RS12325	612225..612500	+	276	WP_014309249.1	hypothetical protein	-
E4651_RS03075	613172..613447	+	276	WP_014303127.1	hypothetical protein	-
E4651_RS03080	613454..614206	+	753	WP_014306660.1	precorrin-6A synthase (deacetylating)	-
E4651_RS03085	614225..614482	-	258	WP_010934589.1	mycoredoxin	-
E4651_RS03090	614503..615006	-	504	WP_050859281.1	dihydrofolate reductase	-
E4651_RS03095	615006..615818	-	813	WP_014303130.1	thymidylate synthase	-
E4651_RS03100	615912..616670	-	759	WP_010934592.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (45-127)

Antitoxin

• Antitoxin SocA-like, Panacea domain (23-116)

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 16477.60 Da
• Isoelectric Point: 7.7987

>T123023 WP_014303124.1 NZ_CP038504:c611176-610724 [Corynebacterium diphtheriae]
VSGNSGASPQDMVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLF
KLANGHYFQDGNKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Nucleotide

• Length: 453 bp

>T123023 NZ_CP038504:c611176-610724 [Corynebacterium diphtheriae]
GTGTCGGGAAATAGCGGGGCATCACCGCAGGACATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTG
CGGGAAGCGAACAGGTCCTCACAGAGAACCTGAACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCG
CGATCGCTTCAGTATTTCAATCGTCGTTTGGCGTCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTC
AAGCTGGCAAACGGGCATTACTTCCAAGACGGAAACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAA
TAACGTTCACGTCAGTCCCCCTCGGTCTGATGACGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAG
AAAACGGGATAGCGTTCGTTAGACAAAAGCTTTTGGACTGGACCGTAGACTGA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 20894.43 Da
• Isoelectric Point: 4.7046

>AT123023 WP_082257486.1 NZ_CP038504:c611754-611188 [Corynebacterium diphtheriae]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
STALDSLEQAADDVATENAETLRLLAFI

Nucleotide

• Length: 567 bp

>AT123023 NZ_CP038504:c611754-611188 [Corynebacterium diphtheriae]
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGTTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCGTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCACGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTACTGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG