Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
| Location | 5982..6570 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP038501 | ||
| Organism | Acinetobacter baumannii strain CIAT758 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | N8SM64 |
| Locus tag | E4664_RS19850 | Protein ID | WP_000438825.1 |
| Coordinates | 6283..6570 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | D3JXQ4 |
| Locus tag | E4664_RS19845 | Protein ID | WP_004728120.1 |
| Coordinates | 5982..6296 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E4664_RS19795 | 1059..1379 | + | 321 | WP_000897309.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| E4664_RS19800 | 1372..1644 | + | 273 | WP_094069338.1 | helix-turn-helix domain-containing protein | - |
| E4664_RS19805 | 2129..2899 | - | 771 | WP_094069337.1 | hypothetical protein | - |
| E4664_RS19810 | 2958..3296 | + | 339 | WP_032073153.1 | hypothetical protein | - |
| E4664_RS19815 | 3402..3674 | - | 273 | WP_000369781.1 | helix-turn-helix domain-containing protein | - |
| E4664_RS19820 | 3667..3987 | - | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| E4664_RS19825 | 4127..4546 | + | 420 | WP_001180106.1 | SMI1/KNR4 family protein | - |
| E4664_RS19830 | 4626..4907 | - | 282 | WP_000985609.1 | putative addiction module antidote protein | - |
| E4664_RS19835 | 4908..5210 | - | 303 | WP_000286964.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| E4664_RS19840 | 5359..5893 | + | 535 | Protein_12 | hypothetical protein | - |
| E4664_RS19845 | 5982..6296 | - | 315 | WP_004728120.1 | BrnA antitoxin family protein | Antitoxin |
| E4664_RS19850 | 6283..6570 | - | 288 | WP_000438825.1 | BrnT family toxin | Toxin |
| E4664_RS19855 | 6866..7507 | - | 642 | WP_167850447.1 | TetR/AcrR family transcriptional regulator C-terminal domain-containing protein | - |
| E4664_RS19860 | 7573..8760 | + | 1188 | WP_087551687.1 | Tet(A)/Tet(B)/Tet(C) family tetracycline efflux MFS transporter | - |
| E4664_RS19865 | 8902..9606 | - | 705 | WP_001067784.1 | IS6-like element IS1006 family transposase | - |
| E4664_RS19870 | 9668..10729 | - | 1062 | Protein_18 | IS66 family transposase | - |
| E4664_RS19875 | 10804..11139 | - | 336 | WP_000618091.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| E4664_RS19880 | 11136..11519 | - | 384 | WP_019836977.1 | IS66 family insertion sequence hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(39) / aac(3)-IId / msr(E) / mph(E) / blaOXA-58 | - | 1..78125 | 78125 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11304.70 Da Isoelectric Point: 5.6205
>T123021 WP_000438825.1 NZ_CP038501:c6570-6283 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
Download Length: 288 bp
>T123021 NZ_CP038501:c6570-6283 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
Antitoxin
Download Length: 105 a.a. Molecular weight: 12200.86 Da Isoelectric Point: 8.4628
>AT123021 WP_004728120.1 NZ_CP038501:c6296-5982 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
Download Length: 315 bp
>AT123021 NZ_CP038501:c6296-5982 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A8TVQ4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A8TRI9 |