Detailed information of TA system TA123016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2328055..2328565
• Replicon: chromosome
• Accession: NZ_CP038500
• Organism: Acinetobacter baumannii strain CIAT758

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q4HKU6
• Locus tag: E4664_RS11445
• Protein ID: WP_000824257.1
• Coordinates: 2328302..2328565 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7S8XU62
• Locus tag: E4664_RS11440
• Protein ID: WP_001165438.1
• Coordinates: 2328055..2328318 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4664_RS11400	2323079..2323465	-	387	WP_031958396.1	hypothetical protein	-
E4664_RS11405	2323602..2323958	-	357	WP_031958395.1	hypothetical protein	-
E4664_RS11410	2324169..2324759	+	591	WP_000676432.1	DUF805 domain-containing protein	-
E4664_RS11415	2325047..2325319	-	273	WP_001172372.1	YkgJ family cysteine cluster protein	-
E4664_RS11420	2325320..2325751	-	432	WP_001118480.1	hypothetical protein	-
E4664_RS11425	2325766..2326425	-	660	Protein_2237	hypothetical protein	-
E4664_RS11430	2326440..2327438	+	999	WP_034129546.1	hypothetical protein	-
E4664_RS11435	2327435..2327701	+	267	WP_000570798.1	AlpA family phage regulatory protein	-
E4664_RS11440	2328055..2328318	+	264	WP_001165438.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
E4664_RS11445	2328302..2328565	+	264	WP_000824257.1	Txe/YoeB family addiction module toxin	Toxin
E4664_RS11450	2328672..2329878	+	1207	Protein_2242	IS256-like element ISAba26 family transposase	-
E4664_RS11455	2330093..2331280	-	1188	WP_002036368.1	DUF4268 domain-containing protein	-
E4664_RS11460	2331380..2332588	-	1209	WP_034129567.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10337.91 Da
• Isoelectric Point: 9.0098

>T123016 WP_000824257.1 NZ_CP038500:2328302-2328565 [Acinetobacter baumannii]
MKRKTSFTPTAWEDYVYWQNQDKKTLKRINTLIKECLRTPFDGIGKPEPLLGDLAGLWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T123016 NZ_CP038500:2328302-2328565 [Acinetobacter baumannii]
ATGAAACGGAAGACTAGTTTTACTCCAACAGCTTGGGAGGATTATGTATATTGGCAAAACCAAGACAAAAAGACTCTTAA
GCGCATCAATACATTAATCAAAGAGTGTCTTCGTACCCCCTTTGATGGTATTGGCAAGCCTGAACCATTACTCGGTGATT
TAGCAGGTTTGTGGAGCAGACGAATAGATGAAAAAAATAGATTAGTCTATGAAGTAACTGATGTAGCGATAACTATCATT
TCTTGTCGTTATCACTACGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9796.01 Da
• Isoelectric Point: 4.6112

>AT123016 WP_001165438.1 NZ_CP038500:2328055-2328318 [Acinetobacter baumannii]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLHLMSSPSNAAHLAKSIAELRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT123016 NZ_CP038500:2328055-2328318 [Acinetobacter baumannii]
ATGCAAATTTTCACTTATACCGATGCTCGCAATAATCTGAAAACGGTTTTAGACCGTGTCATTGATGATTCAGATGTTGC
AGTAATTACGAGAAAAGAAGGTCAACATGCAGTTGTAATGGGACAAGACTATTACAATAGTATAATGGAGACATTGCACC
TCATGTCTTCTCCAAGTAATGCAGCACACCTAGCGAAATCAATTGCAGAATTACGGGCATCTAAAGCAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A4Q4HKU6