123015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2290659..2292400 Replicon chromosome
Accession NZ_CP038500
Organism Acinetobacter baumannii strain CIAT758

Toxin (Protein)


Gene name pmenT Uniprot ID N9S537
Locus tag E4664_RS11305 Protein ID WP_000233088.1
Coordinates 2291744..2292400 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A7U4WEK7
Locus tag E4664_RS11300 Protein ID WP_000622036.1
Coordinates 2290659..2291744 (-) Length 362 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4664_RS11285 2286758..2287847 + 1090 WP_135536536.1 IS4-like element ISAba1 family transposase -
E4664_RS11290 2287950..2289038 + 1089 WP_001153944.1 DUF898 domain-containing protein -
E4664_RS11295 2289059..2290150 + 1092 WP_000076010.1 M48 family metallopeptidase -
E4664_RS11300 2290659..2291744 - 1086 WP_000622036.1 macro domain-containing protein Antitoxin
E4664_RS11305 2291744..2292400 - 657 WP_000233088.1 DUF4433 domain-containing protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2103117..2325475 222358
- flank IS/Tn - - 2286758..2287792 1034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(18-218)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25316.92 Da        Isoelectric Point: 7.1033

>T123015 WP_000233088.1 NZ_CP038500:c2292400-2291744 [Acinetobacter baumannii]
MVGRNYSDVLNPQKALIWRIVHRDNIPWILENGLHSSNSPTQCVNWVQIGSPELIEKRQLHPVPVGKKGVLSDYIPFYFT
PFSPMLLNIKSGRGGVRQRTNDEIVILVSSLYQLQQQQIPFVFTNSHAYYQWAEFYTDLSSLNEIDWSILQARDFKRDMD
DPAKFERYQAEALVHQHCPTKVLIGVICYTETVKAQIEQWLQQADVNIPVHVRQGVYF

Download         Length: 657 bp

>T123015 NZ_CP038500:c2292400-2291744 [Acinetobacter baumannii]
ATGGTTGGACGTAATTATAGTGATGTACTCAATCCGCAAAAGGCATTGATTTGGCGTATTGTGCATCGTGATAATATTCC
GTGGATATTAGAAAATGGCTTACATAGCAGCAATAGTCCAACACAATGTGTAAATTGGGTTCAGATTGGCAGTCCAGAAC
TGATTGAGAAAAGACAACTGCATCCTGTTCCTGTAGGGAAAAAGGGTGTGCTAAGTGACTATATTCCATTTTATTTCACA
CCATTTTCACCTATGCTGCTGAATATAAAGAGTGGCCGTGGCGGTGTACGTCAGCGTACTAATGATGAAATTGTTATTTT
AGTTTCTAGTTTGTATCAGCTACAGCAACAGCAAATTCCTTTTGTTTTTACAAATAGTCATGCCTATTACCAATGGGCTG
AATTCTATACAGATTTATCTAGCTTAAATGAGATCGATTGGTCAATATTACAGGCAAGAGATTTTAAAAGAGATATGGAT
GATCCTGCGAAGTTTGAACGTTATCAAGCCGAAGCGTTAGTTCATCAACACTGCCCAACAAAAGTATTGATTGGGGTGAT
ATGTTATACTGAAACAGTTAAAGCTCAAATAGAACAGTGGCTGCAACAAGCAGATGTTAATATTCCTGTGCATGTGAGAC
AAGGGGTGTATTTCTAA

Antitoxin


Download         Length: 362 a.a.        Molecular weight: 41025.15 Da        Isoelectric Point: 5.8156

>AT123015 WP_000622036.1 NZ_CP038500:c2291744-2290659 [Acinetobacter baumannii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPKNMAAYSQACKAGQVTTGKMFVTETNELMGARWIINFPTK
QHWRDKSKLQWIEDGLQDLKKFIIDHQVKSIAIPPLGAGNGGLEWSRVKSKIETELSDLEYVDILIFEPTTQYQNVAKKI
GVSQLTPARAMIAELVRRYWVLGIECSLLEIQKLAWFLQRVIEQKQLPNELKLNFQANYYGPYASNLDHLLNAMDGSYLK
SDKRIPDCDPLDVIWFNDQQKSKVQGYLISEAKEYMAAVEGAATLIEGFESPFGMELLATVDWLIYKEGYQPNVESIQEG
LANWSAGERWARRKSDLFKAEHIQFALQKLDGFAYSYPDVT

Download         Length: 1086 bp

>AT123015 NZ_CP038500:c2291744-2290659 [Acinetobacter baumannii]
ATGATTCGTTATACAACAGGAAACTTATTAGATGCTCCTGTAGAAGCATTGGTAAATACCGTGAATACCGTTGGTGTAAT
GGGTAAAGGTATTGCTTTAATGTTTAAGGAGCGTTTTCCAAAAAACATGGCAGCTTATAGTCAAGCGTGCAAAGCTGGAC
AGGTTACAACTGGAAAAATGTTTGTGACTGAAACTAATGAGTTAATGGGCGCACGTTGGATTATTAACTTTCCAACTAAA
CAGCATTGGCGGGATAAATCCAAACTCCAATGGATTGAAGATGGTTTGCAGGATCTTAAAAAGTTCATCATTGATCATCA
AGTTAAATCTATTGCAATTCCACCATTAGGTGCGGGTAATGGTGGGTTAGAGTGGAGTCGTGTTAAATCAAAAATTGAGA
CAGAATTATCCGATTTAGAGTATGTGGATATTTTGATTTTTGAACCAACCACACAGTATCAAAACGTGGCAAAGAAAATA
GGTGTATCACAACTTACACCAGCACGAGCCATGATTGCAGAGTTAGTACGTCGTTATTGGGTATTGGGGATTGAATGTAG
TCTATTAGAAATCCAAAAACTGGCATGGTTTTTACAGCGAGTTATTGAGCAAAAACAATTACCAAATGAATTGAAGCTTA
ATTTTCAGGCGAACTATTATGGTCCTTATGCTTCTAATTTAGACCATTTGTTGAATGCAATGGATGGTAGCTATCTCAAA
TCGGACAAGCGAATTCCTGATTGTGACCCCTTAGATGTGATTTGGTTCAATGATCAGCAAAAAAGTAAAGTTCAAGGTTA
TCTGATTAGTGAAGCAAAAGAGTATATGGCTGCTGTAGAAGGAGCTGCAACATTGATAGAGGGTTTTGAATCACCATTTG
GTATGGAGCTTTTGGCAACAGTAGATTGGCTTATCTATAAGGAAGGTTATCAACCTAATGTTGAATCAATTCAAGAAGGG
TTAGCGAATTGGAGTGCAGGTGAGCGTTGGGCAAGACGGAAATCTGATTTATTCAAAGCAGAGCATATTCAATTTGCATT
ACAAAAATTAGATGGTTTTGCTTATTCTTATCCAGATGTAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9S537

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4WEK7

References