Detailed information of TA system TA123013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2464217..2465127
• Replicon: chromosome
• Accession: NZ_CP038499
• Organism: Dickeya dianthicola strain LAR.16.03.LID

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: E4659_RS11380
• Protein ID: WP_024105930.1
• Coordinates: 2464657..2465127 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A3A4C852
• Locus tag: E4659_RS11375
• Protein ID: WP_024105929.1
• Coordinates: 2464217..2464660 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4659_RS11350 (E4659_11510)	2459274..2459945	+	672	WP_024105924.1	dethiobiotin synthase	-
E4659_RS11355 (E4659_11515)	2460220..2460576	-	357	WP_024108773.1	DUF1283 family protein	-
E4659_RS11360 (E4659_11520)	2460782..2461531	-	750	WP_024105926.1	bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG	-
E4659_RS11365 (E4659_11525)	2461835..2463061	-	1227	WP_024105927.1	glycosyl transferase	-
E4659_RS11370 (E4659_11530)	2463080..2463907	-	828	WP_024105928.1	mannosyl-3-phosphoglycerate phosphatase-related protein	-
E4659_RS11375 (E4659_11535)	2464217..2464660	+	444	WP_024105929.1	DUF2384 domain-containing protein	Antitoxin
E4659_RS11380 (E4659_11540)	2464657..2465127	+	471	WP_024105930.1	RES family NAD+ phosphorylase	Toxin
E4659_RS11385 (E4659_11545)	2465133..2465420	+	288	WP_024105931.1	hypothetical protein	-
E4659_RS11390 (E4659_11550)	2465966..2467954	+	1989	WP_024108774.1	AAA family ATPase	-
E4659_RS11395 (E4659_11555)	2467965..2469887	+	1923	WP_024108775.1	UvrD-helicase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (16-147)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17578.95 Da
• Isoelectric Point: 4.7269

>T123013 WP_024105930.1 NZ_CP038499:2464657-2465127 [Dickeya dianthicola]
MILYRLTKTKYLSTVWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAHILDYYTLLRIDVPDDHIQSVNMN
DLPENWAEEDAPPELAAYGDAWCFTKSSIALRVPSTLSPVEFNYLLNPEHPDFSSIIQNADTIPFQFDSRLKPAIK

Nucleotide

• Length: 471 bp

>T123013 NZ_CP038499:2464657-2465127 [Dickeya dianthicola]
TTGATTCTCTACAGGCTGACCAAGACAAAATATCTTTCTACAGTCTGGACGGGATATGGGGCAAAAGAGGCAGGAGGTCG
CTGGAACAGTGTAGGTGTCTCGATGGTATATGTGTCTGAAACAGCATCGCTTACGATGCTTGAGACGCTTGTACATCTGC
ATGCTGCACATATTCTGGATTATTATACTCTGCTGCGTATTGATGTCCCTGATGACCATATTCAGAGCGTCAATATGAAC
GACTTGCCAGAAAATTGGGCTGAAGAAGACGCGCCGCCTGAGCTTGCTGCTTACGGTGATGCTTGGTGCTTTACCAAAAG
TTCGATAGCCTTGCGTGTCCCCAGCACTTTATCTCCCGTGGAATTTAACTACCTTTTAAACCCCGAGCACCCTGACTTCT
CCTCGATCATCCAGAACGCTGACACCATTCCGTTCCAGTTTGATAGCAGGCTGAAACCGGCGATTAAATAG

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16506.81 Da
• Isoelectric Point: 9.6195

>AT123013 WP_024105929.1 NZ_CP038499:2464217-2464660 [Dickeya dianthicola]
MKTFSLSTTQTRPPRLWQVAGLNNSDGVALLGQINEGLDGTVANVIIDWAKITQNDLRKMSGIPSTTFSRSRKARFTADQ
SERLVRIIRVIDRAVELFEGDKDEAQKWLNEPNRALSWKVPAELMASETGAYEVMKLITRLEHGAYS

Nucleotide

• Length: 444 bp

>AT123013 NZ_CP038499:2464217-2464660 [Dickeya dianthicola]
ATGAAAACATTTAGCTTATCCACGACACAGACCCGGCCGCCACGCTTGTGGCAGGTTGCGGGGTTAAACAATTCTGATGG
TGTAGCACTGCTGGGCCAGATTAACGAAGGCCTTGATGGCACAGTTGCAAACGTGATCATTGACTGGGCAAAGATCACGC
AGAACGACCTGCGCAAAATGTCCGGTATACCGTCCACGACATTCAGTCGTAGCCGGAAAGCCCGATTCACCGCCGACCAA
AGTGAGCGACTGGTGCGCATTATTCGCGTTATAGATCGGGCTGTAGAACTGTTCGAGGGTGATAAAGACGAGGCCCAGAA
ATGGTTGAATGAGCCAAACAGAGCACTGAGCTGGAAAGTGCCAGCGGAACTGATGGCCTCCGAAACCGGCGCTTACGAGG
TCATGAAATTGATTACACGCCTGGAGCATGGGGCATACTCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A3A4C852