Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1676106..1676659 Replicon chromosome
Accession NZ_CP038499
Organism Dickeya dianthicola strain LAR.16.03.LID

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3A4C6R7
Locus tag E4659_RS07835 Protein ID WP_024108941.1
Coordinates 1676345..1676659 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3A4CC32
Locus tag E4659_RS07830 Protein ID WP_024108942.1
Coordinates 1676106..1676342 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4659_RS07820 (E4659_07935) 1672907..1674136 - 1230 WP_024108553.1 DNA cytosine methyltransferase -
E4659_RS07825 (E4659_07940) 1674835..1675779 + 945 WP_116587116.1 zincin-like metallopeptidase domain-containing protein -
E4659_RS07830 (E4659_07945) 1676106..1676342 + 237 WP_024108942.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
E4659_RS07835 (E4659_07950) 1676345..1676659 + 315 WP_024108941.1 CcdB family protein Toxin
E4659_RS07840 (E4659_07960) 1677139..1677921 + 783 WP_024108940.1 hypothetical protein -
E4659_RS07845 (E4659_07965) 1678208..1678954 - 747 WP_024108939.1 MobC family replication-relaxation protein -
E4659_RS07850 (E4659_07970) 1678963..1680726 - 1764 WP_024108938.1 type IV secretion system DNA-binding domain-containing protein -
E4659_RS07855 (E4659_07980) 1681310..1681618 - 309 WP_024108937.1 TrbM/KikA/MpfK family conjugal transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp 1646935..1708873 61938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11457.41 Da        Isoelectric Point: 7.9859

>T123002 WP_024108941.1 NZ_CP038499:1676345-1676659 [Dickeya dianthicola]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMAHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T123002 NZ_CP038499:1676345-1676659 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9067.12 Da        Isoelectric Point: 5.8500

>AT123002 WP_024108942.1 NZ_CP038499:1676106-1676342 [Dickeya dianthicola]
MTAKQRNTQSVTMTVERALLLRAREAGINLSATLTTALDAELRRYEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT123002 NZ_CP038499:1676106-1676342 [Dickeya dianthicola]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A4C6R7

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CC32

References