Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1357218..1357843 | Replicon | chromosome |
Accession | NZ_CP038499 | ||
Organism | Dickeya dianthicola strain LAR.16.03.LID |
Toxin (Protein)
Gene name | Hha | Uniprot ID | E0SD87 |
Locus tag | E4659_RS06380 | Protein ID | WP_009114000.1 |
Coordinates | 1357218..1357421 (-) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A0A3A4CQB3 |
Locus tag | E4659_RS06385 | Protein ID | WP_024104994.1 |
Coordinates | 1357475..1357843 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E4659_RS06350 (E4659_06475) | 1352691..1353029 | + | 339 | WP_024104989.1 | P-II family nitrogen regulator | - |
E4659_RS06355 (E4659_06480) | 1353072..1354364 | + | 1293 | WP_024104990.1 | ammonium transporter AmtB | - |
E4659_RS06360 (E4659_06485) | 1354474..1355337 | - | 864 | WP_024108455.1 | acyl-CoA thioesterase II | - |
E4659_RS06365 (E4659_06490) | 1355609..1356166 | + | 558 | WP_024108456.1 | YbaY family lipoprotein | - |
E4659_RS06370 (E4659_06495) | 1356195..1356524 | - | 330 | WP_024104993.1 | MGMT family protein | - |
E4659_RS06380 (E4659_06505) | 1357218..1357421 | - | 204 | WP_009114000.1 | HHA domain-containing protein | Toxin |
E4659_RS06385 (E4659_06510) | 1357475..1357843 | - | 369 | WP_024104994.1 | Hha toxicity modulator TomB | Antitoxin |
E4659_RS06390 (E4659_06515) | 1358352..1358495 | - | 144 | WP_013316871.1 | type B 50S ribosomal protein L36 | - |
E4659_RS06395 (E4659_06520) | 1358511..1358762 | - | 252 | WP_024108457.1 | type B 50S ribosomal protein L31 | - |
E4659_RS06400 (E4659_06525) | 1358933..1362082 | - | 3150 | WP_024108458.1 | efflux RND transporter permease subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8133.51 Da Isoelectric Point: 8.8500
>T123000 WP_009114000.1 NZ_CP038499:c1357421-1357218 [Dickeya dianthicola]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR
Download Length: 204 bp
>T123000 NZ_CP038499:c1357421-1357218 [Dickeya dianthicola]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAAATACGTTCGTTAA
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAAATACGTTCGTTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14242.11 Da Isoelectric Point: 5.1811
>AT123000 WP_024104994.1 NZ_CP038499:c1357843-1357475 [Dickeya dianthicola]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRSWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWRKSKSQLFRMFSEKSICTVVKT
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRSWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWRKSKSQLFRMFSEKSICTVVKT
Download Length: 369 bp
>AT123000 NZ_CP038499:c1357843-1357475 [Dickeya dianthicola]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGATAGCAGTCGTAGCTGGGTGAATGACCCGACTTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCTGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGTAACTACGGTATAAATGACGCCGAGTTGCAGAAATGGCGAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGATAGCAGTCGTAGCTGGGTGAATGACCCGACTTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCTGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGTAACTACGGTATAAATGACGCCGAGTTGCAGAAATGGCGAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X3RNQ0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3A4CQB3 |