Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1357218..1357843 Replicon chromosome
Accession NZ_CP038499
Organism Dickeya dianthicola strain LAR.16.03.LID

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag E4659_RS06380 Protein ID WP_009114000.1
Coordinates 1357218..1357421 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3A4CQB3
Locus tag E4659_RS06385 Protein ID WP_024104994.1
Coordinates 1357475..1357843 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4659_RS06350 (E4659_06475) 1352691..1353029 + 339 WP_024104989.1 P-II family nitrogen regulator -
E4659_RS06355 (E4659_06480) 1353072..1354364 + 1293 WP_024104990.1 ammonium transporter AmtB -
E4659_RS06360 (E4659_06485) 1354474..1355337 - 864 WP_024108455.1 acyl-CoA thioesterase II -
E4659_RS06365 (E4659_06490) 1355609..1356166 + 558 WP_024108456.1 YbaY family lipoprotein -
E4659_RS06370 (E4659_06495) 1356195..1356524 - 330 WP_024104993.1 MGMT family protein -
E4659_RS06380 (E4659_06505) 1357218..1357421 - 204 WP_009114000.1 HHA domain-containing protein Toxin
E4659_RS06385 (E4659_06510) 1357475..1357843 - 369 WP_024104994.1 Hha toxicity modulator TomB Antitoxin
E4659_RS06390 (E4659_06515) 1358352..1358495 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
E4659_RS06395 (E4659_06520) 1358511..1358762 - 252 WP_024108457.1 type B 50S ribosomal protein L31 -
E4659_RS06400 (E4659_06525) 1358933..1362082 - 3150 WP_024108458.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T123000 WP_009114000.1 NZ_CP038499:c1357421-1357218 [Dickeya dianthicola]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T123000 NZ_CP038499:c1357421-1357218 [Dickeya dianthicola]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAAATACGTTCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14242.11 Da        Isoelectric Point: 5.1811

>AT123000 WP_024104994.1 NZ_CP038499:c1357843-1357475 [Dickeya dianthicola]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRSWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWRKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT123000 NZ_CP038499:c1357843-1357475 [Dickeya dianthicola]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGATAGCAGTCGTAGCTGGGTGAATGACCCGACTTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCTGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGTAACTACGGTATAAATGACGCCGAGTTGCAGAAATGGCGAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CQB3

References