Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1330632..1331257 Replicon chromosome
Accession NZ_CP038498
Organism Pectobacterium punjabense strain SS95

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag E2566_RS05930 Protein ID WP_005976087.1
Coordinates 1330632..1330835 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag E2566_RS05935 Protein ID WP_005976089.1
Coordinates 1330889..1331257 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2566_RS05900 1325669..1326007 + 339 WP_002208627.1 P-II family nitrogen regulator -
E2566_RS05905 1326047..1327333 + 1287 WP_165800659.1 ammonium transporter AmtB -
E2566_RS05910 1327694..1328557 - 864 WP_107168395.1 acyl-CoA thioesterase II -
E2566_RS05915 1328770..1329354 + 585 WP_107168394.1 YbaY family lipoprotein -
E2566_RS05920 1329374..1329694 - 321 WP_107168393.1 MGMT family protein -
E2566_RS05930 1330632..1330835 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
E2566_RS05935 1330889..1331257 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
E2566_RS05940 1331854..1331997 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
E2566_RS05945 1332015..1332263 - 249 WP_107168401.1 type B 50S ribosomal protein L31 -
E2566_RS05950 1332493..1335621 - 3129 WP_107168392.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T122992 WP_005976087.1 NZ_CP038498:c1330835-1330632 [Pectobacterium punjabense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T122992 NZ_CP038498:c1330835-1330632 [Pectobacterium punjabense]
ATGAAAAAAATCGATTATTTGATGCGTTTGCGTAAATGCACAACCATAGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAGCTGGAGATGTTCTTTTCTGCAGCCGATCATCGTCTGGCAGAGCTGACGATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT122992 WP_005976089.1 NZ_CP038498:c1331257-1330889 [Pectobacterium punjabense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT122992 NZ_CP038498:c1331257-1330889 [Pectobacterium punjabense]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGATGAAAGCATAGC
AACGTTAGGCGATAGCAGTCATGGCTGGGTCAATGATCCAACCTCTGCGATCAATCTCCAATTAAATGAGCTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTAGAAAAGTATTTA
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGATGCTGAACTACGACGCTGGCAGAAGTCTAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References