Detailed information of TA system TA122987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-DnaT
• Location: 391846..392377
• Replicon: chromosome
• Accession: NZ_CP038498
• Organism: Pectobacterium punjabense strain SS95

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: E2566_RS01820
• Protein ID: WP_107170910.1
• Coordinates: 392090..392377 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: A0A1V2R9J2
• Locus tag: E2566_RS01815
• Protein ID: WP_039282788.1
• Coordinates: 391846..392100 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2566_RS01790	386958..387548	-	591	WP_005975525.1	DnaA initiator-associating protein DiaA	-
E2566_RS01795	387590..387946	-	357	WP_205543243.1	YraN family protein	-
E2566_RS01800	387943..389961	-	2019	WP_107170760.1	penicillin-binding protein activator	-
E2566_RS01805	390024..390911	+	888	WP_107170761.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
E2566_RS01815	391846..392100	+	255	WP_039282788.1	plasmid stabilization protein	Antitoxin
E2566_RS01820	392090..392377	+	288	WP_107170910.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E2566_RS01825	392557..393342	+	786	WP_107170911.1	4,5-DOPA dioxygenase extradiol	-
E2566_RS01830	393549..394709	-	1161	WP_107170912.1	glutathionylspermidine synthase family protein	-
E2566_RS01835	394721..395389	-	669	WP_107170913.1	DUF1190 family protein	-
E2566_RS01840	395671..397065	-	1395	WP_107170914.1	outer membrane channel protein TolC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11022.00 Da
• Isoelectric Point: 10.8186

>T122987 WP_107170910.1 NZ_CP038498:392090-392377 [Pectobacterium punjabense]
MIYKLKFVPSAMKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLRSAGYRLVYLVQDEAITVMVMGVGK
REGSQIYSDTKGRSA

Nucleotide

• Length: 288 bp

>T122987 NZ_CP038498:392090-392377 [Pectobacterium punjabense]
ATGATCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAGCTAGGGCATCCTGTCCGGGAACAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAAACCCTCGTGTTCCTTCAGCCCAGCTTCATGGCCGTAAAGACCAGTATAAAATTA
AACTTAGGTCCGCTGGCTACAGGCTGGTGTATTTGGTCCAGGATGAGGCCATTACTGTGATGGTTATGGGAGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACGAAAGGTCGCTCTGCTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9208.38 Da
• Isoelectric Point: 3.7947

>AT122987 WP_039282788.1 NZ_CP038498:391846-392100 [Pectobacterium punjabense]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
LDDL

Nucleotide

• Length: 255 bp

>AT122987 NZ_CP038498:391846-392100 [Pectobacterium punjabense]
ATGGCTTTCAACATCCTAACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTTCGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCGGCGTTCTACTGTGTGCCTCCTGCTGTATTCGCCTATTTAA
TGGAACTGGCTGAAGATGCAGAGCTGGGGCGTACCGTTGATGATCGGATGTCAGAGCTAGCTGACGCGGAAGAGATTTCG
CTCGATGATCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1V2R9J2