Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1907757..1908235 Replicon chromosome
Accession NZ_CP038496
Organism Escherichia coli O157:H7 strain TT12A

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E5F08_RS08705 Protein ID WP_001303876.1
Coordinates 1907757..1908044 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E5F08_RS08710 Protein ID WP_000536233.1
Coordinates 1908044..1908235 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5F08_RS08675 1902906..1905377 - 2472 WP_000034474.1 exonuclease -
E5F08_RS08680 1905471..1905662 - 192 WP_001098307.1 DUF1482 family protein -
E5F08_RS08685 1905659..1905847 - 189 WP_000413705.1 cell division inhibition protein DicB -
E5F08_RS08690 1906421..1906606 + 186 WP_001133046.1 hypothetical protein -
E5F08_RS08695 1906793..1907182 - 390 WP_000394511.1 hypothetical protein -
E5F08_RS08700 1907324..1907479 - 156 WP_000379575.1 DUF1391 family protein -
E5F08_RS08705 1907757..1908044 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5F08_RS08710 1908044..1908235 - 192 WP_000536233.1 hypothetical protein Antitoxin
E5F08_RS08715 1908263..1908664 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E5F08_RS08720 1908773..1909045 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E5F08_RS08725 1909029..1909454 + 426 WP_000693855.1 Rha family transcriptional regulator -
E5F08_RS08730 1909661..1910116 - 456 WP_000273724.1 hypothetical protein -
E5F08_RS08735 1910195..1911286 + 1092 WP_001205823.1 hypothetical protein -
E5F08_RS08740 1911293..1912039 + 747 WP_000788751.1 ATP-binding protein -
E5F08_RS08745 1912061..1912831 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T122961 WP_001303876.1 NZ_CP038496:c1908044-1907757 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T122961 NZ_CP038496:c1908044-1907757 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT122961 WP_000536233.1 NZ_CP038496:c1908235-1908044 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT122961 NZ_CP038496:c1908235-1908044 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References