Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1907754..1908232 Replicon chromosome
Accession NZ_CP038494
Organism Escherichia coli O157:H7 strain TT12B

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E5F07_RS08695 Protein ID WP_001303876.1
Coordinates 1907754..1908041 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E5F07_RS08700 Protein ID WP_000536233.1
Coordinates 1908041..1908232 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5F07_RS08665 1902903..1905374 - 2472 WP_000034474.1 exonuclease -
E5F07_RS08670 1905468..1905659 - 192 WP_001098307.1 DUF1482 family protein -
E5F07_RS08675 1905656..1905844 - 189 WP_000413705.1 cell division inhibition protein DicB -
E5F07_RS08680 1906418..1906603 + 186 WP_001133046.1 hypothetical protein -
E5F07_RS08685 1906790..1907179 - 390 WP_000394511.1 hypothetical protein -
E5F07_RS08690 1907321..1907476 - 156 WP_000379575.1 DUF1391 family protein -
E5F07_RS08695 1907754..1908041 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5F07_RS08700 1908041..1908232 - 192 WP_000536233.1 hypothetical protein Antitoxin
E5F07_RS08705 1908260..1908661 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E5F07_RS08710 1908770..1909042 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E5F07_RS08715 1909026..1909451 + 426 WP_000693855.1 Rha family transcriptional regulator -
E5F07_RS08720 1909658..1910113 - 456 WP_000273724.1 hypothetical protein -
E5F07_RS08725 1910192..1911283 + 1092 WP_001205823.1 hypothetical protein -
E5F07_RS08730 1911290..1912036 + 747 WP_000788751.1 ATP-binding protein -
E5F07_RS08735 1912058..1912828 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T122930 WP_001303876.1 NZ_CP038494:c1908041-1907754 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T122930 NZ_CP038494:c1908041-1907754 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT122930 WP_000536233.1 NZ_CP038494:c1908232-1908041 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT122930 NZ_CP038494:c1908232-1908041 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References