Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3534907..3535704 Replicon chromosome
Accession NZ_CP038471
Organism Enterobacter roggenkampii strain BP10374

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag E4005_RS16970 Protein ID WP_032651255.1
Coordinates 3535183..3535704 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag E4005_RS16965 Protein ID WP_008499829.1
Coordinates 3534907..3535176 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4005_RS16935 3530167..3530703 - 537 WP_135346066.1 OmpH family outer membrane protein -
E4005_RS16940 3531128..3532369 + 1242 WP_135346067.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
E4005_RS16945 3532403..3532630 - 228 WP_008499832.1 YccJ family protein -
E4005_RS16950 3532651..3533247 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
E4005_RS16955 3533639..3533809 + 171 WP_013097201.1 general stress protein -
E4005_RS16960 3533928..3534845 + 918 WP_025912980.1 DMT family transporter -
E4005_RS16965 3534907..3535176 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
E4005_RS16970 3535183..3535704 + 522 WP_032651255.1 GNAT family N-acetyltransferase Toxin
E4005_RS16975 3535778..3537100 - 1323 WP_104948907.1 pyrimidine utilization transport protein G -
E4005_RS16980 3537122..3537616 - 495 WP_023327078.1 pyrimidine utilization flavin reductase protein F -
E4005_RS16985 3537626..3538216 - 591 WP_106106141.1 malonic semialdehyde reductase -
E4005_RS16990 3538226..3539026 - 801 WP_106106140.1 pyrimidine utilization protein D -
E4005_RS16995 3539034..3539420 - 387 WP_008499822.1 pyrimidine utilization protein C -
E4005_RS17000 3539432..3540121 - 690 WP_047745127.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T122911 WP_032651255.1 NZ_CP038471:3535183-3535704 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

>T122911 NZ_CP038471:3535183-3535704 [Enterobacter roggenkampii]
GTGGACAATCTCACGATCGAAATGTTTTCAGAGGGAAAAGACTATGATTTCAGGGACTTCGATTGTGGTGAACCCTCGCT
AAATGTCTTCCTCACAGAACATCTGGTGCGTCAGCACAATGGGCGTATTTTACGAGGCTATTTGCTTAAAGATCGCGATG
GTCCGCGAGTCCTGGGCTATTACACGTTGTCTGGTAGTTGCTTTGAAAAAGCGATGCTGCCTTCTAAGACTCAGCAGCGT
CGGATCCCTTATAGCAACGTACCGAGCGTAACGCTGGGACGTCTGGCGATACATAAAGACTTACAGGGGCTGGAGTGGGG
AACGACGCTCGTCACGCATGCCATGCGGGTTGTCTATCTGGCATCGCAGGCGGTGGGCGTACACGGAATATTTGTTGATG
CACTCAACGACCAGGCAAAACAATTTTATCTGAAGCAGGGCTTTATTCCGCTGACGGATGAAAACAGCCATTCTCTTTTC
TTTCCTACAAAATCTATCGAACGACTGTTTGAGCAGGCGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT122911 WP_008499829.1 NZ_CP038471:3534907-3535176 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT122911 NZ_CP038471:3534907-3535176 [Enterobacter roggenkampii]
ATGCCAGCACTGAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGGGCAGCGGAAGTCATCGAGCAGCACCGCCGTC
TCGTATTAAACGAAGCATCCTGGAATGCGGTGATGGATGCCATCGACAATCCACCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155TD66

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References