Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2898933..2899553 Replicon chromosome
Accession NZ_CP038471
Organism Enterobacter roggenkampii strain BP10374

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag E4005_RS13900 Protein ID WP_008499287.1
Coordinates 2898933..2899151 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag E4005_RS13905 Protein ID WP_008499288.1
Coordinates 2899179..2899553 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4005_RS13870 2894946..2895206 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
E4005_RS13875 2895209..2895349 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
E4005_RS13880 2895346..2896056 - 711 WP_135345885.1 GNAT family N-acetyltransferase -
E4005_RS13885 2896158..2897618 + 1461 WP_008499284.1 PLP-dependent aminotransferase family protein -
E4005_RS13890 2897590..2898057 - 468 WP_059362219.1 hypothetical protein -
E4005_RS13895 2898175..2898726 - 552 WP_045416680.1 maltose O-acetyltransferase -
E4005_RS13900 2898933..2899151 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
E4005_RS13905 2899179..2899553 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
E4005_RS13910 2900063..2903209 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
E4005_RS13915 2903232..2904425 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T122910 WP_008499287.1 NZ_CP038471:c2899151-2898933 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T122910 NZ_CP038471:c2899151-2898933 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACTAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT122910 WP_008499288.1 NZ_CP038471:c2899553-2899179 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT122910 NZ_CP038471:c2899553-2899179 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References