Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 997249..997906 Replicon chromosome
Accession NZ_CP038471
Organism Enterobacter roggenkampii strain BP10374

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag E4005_RS04830 Protein ID WP_021242050.1
Coordinates 997249..997659 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag E4005_RS04835 Protein ID WP_006178375.1
Coordinates 997640..997906 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4005_RS04810 993242..994975 - 1734 WP_135345484.1 single-stranded-DNA-specific exonuclease RecJ -
E4005_RS04815 994981..995694 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E4005_RS04820 995723..996619 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
E4005_RS04825 996721..997242 + 522 WP_008499710.1 flavodoxin FldB -
E4005_RS04830 997249..997659 - 411 WP_021242050.1 protein YgfX Toxin
E4005_RS04835 997640..997906 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
E4005_RS04840 998201..999181 + 981 WP_008499712.1 tRNA-modifying protein YgfZ -
E4005_RS04845 999266..999925 - 660 WP_021242052.1 hemolysin III family protein -
E4005_RS04850 1000191..1000922 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
E4005_RS04855 1001039..1002472 + 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T122907 WP_021242050.1 NZ_CP038471:c997659-997249 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T122907 NZ_CP038471:c997659-997249 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGCTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAGCAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT122907 WP_006178375.1 NZ_CP038471:c997906-997640 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT122907 NZ_CP038471:c997906-997640 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References