Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3255341..3255951 Replicon chromosome
Accession NZ_CP038469
Organism Citrobacter tructae strain SNU WT2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4Z61_RS16270 Protein ID WP_135323668.1
Coordinates 3255341..3255715 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4Z61_RS16275 Protein ID WP_205746870.1
Coordinates 3255715..3255951 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z61_RS16255 3252844..3253746 + 903 WP_135323665.1 formate dehydrogenase O subunit beta -
E4Z61_RS16260 3253743..3254378 + 636 WP_135323666.1 formate dehydrogenase cytochrome b556 subunit -
E4Z61_RS16265 3254375..3255304 + 930 WP_135323667.1 formate dehydrogenase accessory protein FdhE -
E4Z61_RS16270 3255341..3255715 - 375 WP_135323668.1 type II toxin-antitoxin system VapC family toxin Toxin
E4Z61_RS16275 3255715..3255951 - 237 WP_205746870.1 ribbon-helix-helix protein, CopG family Antitoxin
E4Z61_RS16280 3256158..3257072 + 915 WP_135323669.1 alpha/beta hydrolase -
E4Z61_RS16285 3257112..3258053 - 942 WP_167817561.1 fatty acid biosynthesis protein FabY -
E4Z61_RS16290 3258098..3258535 - 438 WP_135323671.1 D-tyrosyl-tRNA(Tyr) deacylase -
E4Z61_RS16295 3258532..3259404 - 873 WP_135323672.1 virulence factor BrkB family protein -
E4Z61_RS16300 3259398..3259997 - 600 WP_135323673.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13799.96 Da        Isoelectric Point: 8.5257

>T122905 WP_135323668.1 NZ_CP038469:c3255715-3255341 [Citrobacter tructae]
MANGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYNQEHRTRVAMSAFNVIGVSQEIAQRSVAL
RQEYGMKLPDAIILATAQVHRLELVTRNTKDFAGIPGVVTPYEL

Download         Length: 375 bp

>T122905 NZ_CP038469:c3255715-3255341 [Citrobacter tructae]
ATGGCTAATGGGTCGGCACTTTTTGACACCAATATTTTAATCGACTTATTCAGTGGGCGGCGCGAAGCAAAACAAGCGTT
AGAAGCATGGCCACCGCAGAATGCGATTAGCCTTATTACCTGGATGGAAGTGATGGTGGGTGCCAAAAAATATAATCAGG
AGCACCGCACGCGCGTTGCGATGAGCGCGTTTAACGTTATTGGTGTATCGCAGGAAATTGCCCAGCGAAGTGTTGCTCTG
CGCCAGGAGTATGGGATGAAACTTCCGGATGCCATTATTCTGGCGACAGCGCAAGTTCATCGCCTTGAACTGGTCACGCG
TAATACAAAGGACTTTGCCGGAATACCGGGCGTGGTGACGCCATACGAATTGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9223.54 Da        Isoelectric Point: 4.3894

>AT122905 WP_205746870.1 NZ_CP038469:c3255951-3255715 [Citrobacter tructae]
MMIGLDMGRILLDLSDEMIKRLDDLKVQRNLPRAELLREAVEQYLERQSNTTISNALGLWQGCEEDGVEYQRKLREEW

Download         Length: 237 bp

>AT122905 NZ_CP038469:c3255951-3255715 [Citrobacter tructae]
ATGATGATTGGGCTGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAATGATTAAACGACTGGACGATCTCAAAGT
GCAACGCAACCTTCCCCGTGCGGAGTTGTTGCGAGAGGCTGTTGAGCAGTATCTGGAAAGACAGTCAAATACGACTATTT
CCAATGCACTTGGCTTGTGGCAGGGCTGTGAAGAAGACGGTGTGGAATACCAGCGCAAACTGCGTGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References