Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2166540..2167160 Replicon chromosome
Accession NZ_CP038469
Organism Citrobacter tructae strain SNU WT2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag E4Z61_RS11230 Protein ID WP_002892050.1
Coordinates 2166942..2167160 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag E4Z61_RS11225 Protein ID WP_115259201.1
Coordinates 2166540..2166914 (+) Length 125 a.a.

Genomic Context

E4Z61_RS11215E4Z61_RS11220E4Z61_RS11225E4Z61_RS11230E4Z61_RS11235E4Z61_RS11240E4Z61_RS11255E4Z61_RS11245E4Z61_RS11250E4Z61_RS11260E4Z61_RS11265
Location: 2161693..2162883 (1191 bp)
Type: Others
Protein ID: WP_135322832.1
Location: 2162906..2166055 (3150 bp)
Type: Others
Protein ID: WP_135322833.1
Location: 2166540..2166914 (375 bp)
Type: Antitoxin
Protein ID: WP_115259201.1
Location: 2166942..2167160 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Location: 2167346..2167897 (552 bp)
Type: Others
Protein ID: WP_135322834.1
Location: 2168014..2168484 (471 bp)
Type: Others
Protein ID: WP_135322835.1
Location: 2169147..2170700 (1554 bp)
Type: Others
Protein ID: WP_135322837.1
Location: 2168558..2168698 (141 bp)
Type: Others
Protein ID: WP_005125190.1
Location: 2168700..2168960 (261 bp)
Type: Others
Protein ID: WP_135322836.1
Location: 2170764..2171117 (354 bp)
Type: Others
Protein ID: WP_135322838.1
Location: 2171200..2171811 (612 bp)
Type: Others
Protein ID: WP_135322839.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4Z61_RS112152161693..2162883+1191WP_135322832.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
E4Z61_RS112202162906..2166055+3150WP_135322833.1efflux RND transporter permease AcrB-
E4Z61_RS112252166540..2166914+375WP_115259201.1Hha toxicity modulator TomBAntitoxin
E4Z61_RS112302166942..2167160+219WP_002892050.1hemolysin expression modulator HhaToxin
E4Z61_RS112352167346..2167897+552WP_135322834.1maltose O-acetyltransferase-
E4Z61_RS112402168014..2168484+471WP_135322835.1YlaC family protein-
E4Z61_RS112452168558..2168698-141WP_005125190.1type B 50S ribosomal protein L36-
E4Z61_RS112502168700..2168960-261WP_135322836.1type B 50S ribosomal protein L31-
E4Z61_RS112552169147..2170700+1554WP_135322837.1EAL domain-containing protein-
E4Z61_RS112602170764..2171117-354WP_135322838.1DUF1428 family protein-
E4Z61_RS112652171200..2171811-612WP_135322839.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T122904 WP_002892050.1 NZ_CP038469:2166942-2167160 [Citrobacter tructae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T122904 NZ_CP038469:2166942-2167160 [Citrobacter tructae]
ATGTCTGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGCTGCCAGACAATTGACACGCTTGAGCGCGT
TATTGAGAAAAATAAATATGAATTGTCCGACAATGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACGATGAATAAGCTCTACGACAAGATCCCAACTTCCGTTTGGAAATTTATACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14454.26 Da        Isoelectric Point: 5.5653

>AT122904 WP_115259201.1 NZ_CP038469:2166540-2166914 [Citrobacter tructae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT122904 NZ_CP038469:2166540-2166914 [Citrobacter tructae]
ATGGACGAGTACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGCAACCATGGCTGGGTTAATGACCCAACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCACAGATTGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAATTATGGTATTAATACGCAGGATTTGCAGAAATGGCGAAAGTCCGGGAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2P8K6F2

Antitoxin

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Source
ID
Structure
No matching records found

References