Detailed information of TA system TA122895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4910560..4911027
• Replicon: chromosome
• Accession: NZ_CP038467
• Organism: Serratia quinivorans strain PKL:12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4343_RS23050
• Protein ID: WP_135345083.1
• Coordinates: 4910758..4911027 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X2GZW8
• Locus tag: E4343_RS23045
• Protein ID: WP_012146238.1
• Coordinates: 4910560..4910754 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4343_RS23035	4909419..4909784	+	366	WP_112362989.1	DUF596 domain-containing protein	-
E4343_RS23040	4909861..4910415	-	555	WP_012146239.1	spermidine N1-acetyltransferase	-
E4343_RS23045	4910560..4910754	+	195	WP_012146238.1	hypothetical protein	Antitoxin
E4343_RS23050	4910758..4911027	+	270	WP_135345083.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4343_RS23055	4911078..4911716	-	639	WP_017893633.1	phosphoribosylglycinamide formyltransferase	-
E4343_RS23060	4911716..4912753	-	1038	WP_041419010.1	phosphoribosylformylglycinamidine cyclo-ligase	-
E4343_RS23065	4913009..4913635	+	627	WP_017893631.1	uracil phosphoribosyltransferase	-
E4343_RS23070	4913698..4914990	+	1293	WP_112362991.1	uracil permease	-
E4343_RS23075	4915041..4915289	-	249	WP_006316897.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
E4343_RS23080	4915319..4915834	-	516	WP_012146232.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10534.20 Da
• Isoelectric Point: 6.6438

>T122895 WP_135345083.1 NZ_CP038467:4910758-4911027 [Serratia quinivorans]
MRIEWSSEAQEELWSIIDFIDDRNPRAARKLQHEIEAVVLSLPLNPLMHRLGRVDNTREIVVHPNYLIVYRIIGHIEILS
VIHAKREYP

Nucleotide

• Length: 270 bp

>T122895 NZ_CP038467:4910758-4911027 [Serratia quinivorans]
ATGCGGATAGAATGGAGCAGTGAAGCTCAGGAAGAGCTATGGAGCATTATTGATTTTATTGATGACAGAAATCCGCGGGC
TGCGCGAAAATTGCAGCACGAAATCGAAGCGGTAGTCCTTTCTCTGCCGTTAAACCCCTTAATGCATCGTTTGGGTAGGG
TAGATAATACGCGTGAAATTGTCGTCCATCCCAACTACCTGATTGTTTATAGAATCATCGGGCATATAGAAATTCTTAGT
GTTATTCACGCCAAGCGGGAATATCCGTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7279.47 Da
• Isoelectric Point: 10.3798

>AT122895 WP_012146238.1 NZ_CP038467:4910560-4910754 [Serratia quinivorans]
MAIKPPLSTLPVLGSAEQTESYDRWYRAKVESAINSEQPRIPHEQVMTELQARLAAKKKLRKMG

Nucleotide

• Length: 195 bp

>AT122895 NZ_CP038467:4910560-4910754 [Serratia quinivorans]
ATGGCGATAAAACCTCCACTTTCTACCTTGCCGGTGCTGGGTTCGGCCGAACAAACAGAGAGCTACGATCGGTGGTATCG
GGCCAAGGTTGAATCAGCCATTAACAGTGAGCAGCCAAGAATTCCGCACGAACAGGTGATGACTGAACTGCAAGCTCGTT
TAGCAGCAAAGAAAAAATTGCGCAAAATGGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A2X2GZW8