Detailed information of TA system TA122894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4871374..4872026
• Replicon: chromosome
• Accession: NZ_CP038467
• Organism: Serratia quinivorans strain PKL:12

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E4343_RS22920
• Protein ID: WP_115184044.1
• Coordinates: 4871640..4872026 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2X2J553
• Locus tag: E4343_RS22915
• Protein ID: WP_012146268.1
• Coordinates: 4871374..4871637 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4343_RS22900	4867742..4868665	-	924	WP_135345074.1	lipid kinase YegS	-
E4343_RS22905	4869152..4870504	-	1353	WP_135345075.1	tRNA 5-hydroxyuridine modification protein YegQ	-
E4343_RS22910	4870683..4871021	-	339	WP_112364038.1	YegP family protein	-
E4343_RS22915	4871374..4871637	+	264	WP_012146268.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E4343_RS22920	4871640..4872026	+	387	WP_115184044.1	type II toxin-antitoxin system VapC family toxin	Toxin
E4343_RS22925	4872023..4872739	-	717	WP_041418654.1	two-component system response regulator BaeR	-
E4343_RS22930	4872739..4874121	-	1383	WP_012146265.1	two-component system sensor histidine kinase BaeS	-
E4343_RS22935	4874118..4875551	-	1434	WP_135345076.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13985.16 Da
• Isoelectric Point: 7.2420

>T122894 WP_115184044.1 NZ_CP038467:4871640-4872026 [Serratia quinivorans]
MYMFDTNTVSQLFRRHPRLLGLMEKIPPSAVCISSITEAELLYGVAKRQSLTLKATVAAFLDSVTVYAWDSEAAHCYGAM
RAEMTKNGRTMGALDQLIAAHAQSRGATIVTNDKAFAMVPGLAVEDWT

Nucleotide

• Length: 387 bp

>T122894 NZ_CP038467:4871640-4872026 [Serratia quinivorans]
ATGTATATGTTTGATACCAATACGGTCAGCCAGCTCTTTCGTCGGCACCCTCGTCTGCTCGGCTTAATGGAAAAGATCCC
GCCTTCTGCGGTCTGCATTTCCAGTATTACCGAGGCTGAATTGCTCTATGGTGTCGCCAAACGGCAGAGTCTGACGCTGA
AAGCGACGGTTGCGGCATTCCTTGATTCCGTGACGGTCTATGCTTGGGACAGTGAAGCCGCGCATTGCTATGGCGCTATG
CGGGCGGAGATGACAAAAAACGGGCGAACGATGGGGGCTTTGGATCAGCTTATTGCCGCACACGCCCAGAGCCGCGGTGC
GACGATTGTGACTAACGATAAGGCGTTCGCCATGGTGCCAGGCCTGGCAGTGGAAGACTGGACTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10098.43 Da
• Isoelectric Point: 5.1351

>AT122894 WP_012146268.1 NZ_CP038467:4871374-4871637 [Serratia quinivorans]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIAQTQVPQDFLTAEDRQQGMATR
DPFAGEE

Nucleotide

• Length: 264 bp

>AT122894 NZ_CP038467:4871374-4871637 [Serratia quinivorans]
ATGGAAAGAGTCGCGAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGATTACCCGTGGAATTCGAATTCGATACAGA
TCGCGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCGAAATATCCGGCGAAACCTGACAGCTGGGCTCCGC
TGCTGCAAATGATCGCACAAACGCAGGTACCGCAGGACTTCCTGACCGCGGAGGATCGTCAGCAGGGGATGGCCACCCGC
GATCCCTTTGCCGGGGAAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2X2J553