Detailed information of TA system TA122893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 4703811..4704444
• Replicon: chromosome
• Accession: NZ_CP038467
• Organism: Serratia quinivorans strain PKL:12

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E4343_RS22110
• Protein ID: WP_098931989.1
• Coordinates: 4703811..4703987 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: E4343_RS22115
• Protein ID: WP_135345021.1
• Coordinates: 4704037..4704444 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4343_RS22080	4699271..4700149	+	879	WP_135345195.1	ATP-binding protein	-
E4343_RS22085	4700146..4701504	+	1359	WP_135345017.1	replicative DNA helicase	-
E4343_RS22090	4701501..4701866	+	366	WP_135345018.1	RusA family crossover junction endodeoxyribonuclease	-
E4343_RS22095	4701863..4702645	+	783	WP_135345019.1	antitermination protein	-
E4343_RS22105	4703031..4703720	+	690	WP_189636464.1	protein mom	-
E4343_RS22110	4703811..4703987	+	177	WP_098931989.1	type II toxin-antitoxin system HicA family toxin	Toxin
E4343_RS22115	4704037..4704444	+	408	WP_135345021.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E4343_RS22120	4704544..4704921	+	378	WP_135345022.1	hypothetical protein	-
E4343_RS22125	4704911..4705216	+	306	WP_135345023.1	phage holin family protein	-
E4343_RS22130	4705194..4705736	+	543	WP_135345024.1	glycoside hydrolase family 108 protein	-
E4343_RS22135	4705733..4706092	+	360	WP_135345025.1	DUF2570 family protein	-
E4343_RS22140	4706653..4706874	+	222	WP_135345026.1	hypothetical protein	-
E4343_RS22145	4706895..4707092	+	198	WP_135345027.1	hypothetical protein	-
E4343_RS22150	4707323..4707778	+	456	WP_135345028.1	hypothetical protein	-
E4343_RS22155	4707821..4708045	+	225	WP_135345029.1	hypothetical protein	-
E4343_RS22160	4708042..4708380	+	339	WP_135345030.1	HNH endonuclease	-
E4343_RS22165	4708380..4708580	+	201	WP_135345031.1	hypothetical protein	-
E4343_RS22170	4708799..4709263	+	465	WP_135345032.1	phage terminase small subunit P27 family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4692366..4740827	48461

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-61)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6679.84 Da
• Isoelectric Point: 11.1683

>T122893 WP_098931989.1 NZ_CP038467:4703811-4703987 [Serratia quinivorans]
VKQREFQRWLAAQGAEFSNGTNHLKIYLNGKQTIMPRHPGKEIPEPLRKAILKQLGLK

Nucleotide

• Length: 177 bp

>T122893 NZ_CP038467:4703811-4703987 [Serratia quinivorans]
GTGAAACAACGCGAGTTCCAGCGTTGGCTTGCAGCACAAGGGGCGGAGTTTTCAAACGGTACTAACCACTTGAAAATCTA
CCTGAACGGCAAGCAGACGATAATGCCAAGGCATCCGGGGAAGGAAATACCGGAGCCGCTGAGAAAAGCGATTCTCAAGC
AACTTGGCCTTAAATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14788.91 Da
• Isoelectric Point: 4.5348

>AT122893 WP_135345021.1 NZ_CP038467:4704037-4704444 [Serratia quinivorans]
MRYPVKFEHDETGWCISFPDIPEALTGGSTREEALEMAQDALVTAFDFYFEDRRPVPMPSADGEEFVDVPASVAAKVLLL
NAMIATGTTPAELARRLGTRPQDVNRIVTLSHATKIDTIEAALKALGKRLEITAL

Nucleotide

• Length: 408 bp

>AT122893 NZ_CP038467:4704037-4704444 [Serratia quinivorans]
ATGCGATATCCAGTAAAATTTGAGCACGACGAAACCGGGTGGTGTATATCGTTCCCGGATATCCCGGAGGCTTTAACGGG
CGGAAGTACTAGGGAAGAGGCGTTAGAAATGGCGCAAGATGCCCTGGTAACGGCGTTTGATTTTTATTTTGAAGATCGGC
GGCCCGTACCGATGCCAAGCGCTGACGGTGAAGAGTTTGTCGATGTGCCAGCAAGCGTGGCAGCTAAGGTACTACTGCTT
AACGCCATGATAGCCACTGGCACAACACCGGCAGAACTGGCCCGCCGTCTGGGTACGCGCCCACAGGACGTTAACCGGAT
TGTTACCCTAAGCCATGCGACCAAAATCGATACAATCGAGGCCGCACTTAAGGCGCTGGGTAAGCGGTTAGAAATCACCG
CGCTCTAA