Detailed information of TA system TA122891

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4466306..4466975
• Replicon: chromosome
• Accession: NZ_CP038467
• Organism: Serratia quinivorans strain PKL:12

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: E4343_RS20920
• Protein ID: WP_135344956.1
• Coordinates: 4466553..4466975 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2X2H1C0
• Locus tag: E4343_RS20915
• Protein ID: WP_012146600.1
• Coordinates: 4466306..4466572 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4343_RS20890	4461407..4462060	+	654	WP_135344954.1	hypothetical protein	-
E4343_RS20895	4462057..4463382	+	1326	WP_017893860.1	MHS family MFS transporter	-
E4343_RS20900	4463433..4464041	-	609	WP_012146603.1	HD domain-containing protein	-
E4343_RS20905	4464225..4464899	+	675	WP_012146602.1	hemolysin III family protein	-
E4343_RS20910	4464990..4465982	-	993	WP_135344955.1	tRNA-modifying protein YgfZ	-
E4343_RS20915	4466306..4466572	+	267	WP_012146600.1	FAD assembly factor SdhE	Antitoxin
E4343_RS20920	4466553..4466975	+	423	WP_135344956.1	protein YgfX	Toxin
E4343_RS20925	4466975..4467670	+	696	WP_012146598.1	two-component system response regulator CreB	-
E4343_RS20930	4467667..4469085	+	1419	WP_135344957.1	two-component system sensor histidine kinase CreC	-
E4343_RS20935	4469168..4470532	+	1365	WP_017893856.1	cell envelope integrity protein CreD	-
E4343_RS20940	4470569..4471087	-	519	WP_017893855.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16531.41 Da
• Isoelectric Point: 10.5155

>T122891 WP_135344956.1 NZ_CP038467:4466553-4466975 [Serratia quinivorans]
VAQWRCDVRISWRTQLFSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLENQRLGWHGQ
EWQLLKQPWMPRYGILLTLQPVGGKKHRRLWLASDSMAKADWRQLRQRLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T122891 NZ_CP038467:4466553-4466975 [Serratia quinivorans]
GTGGCCCAGTGGCGATGTGACGTCCGTATTTCCTGGCGCACCCAGTTATTTTCGCTGCTGACACATGGCGTATTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTATGGCCCGATCTGGCTGGTGCTACTGACGCTGGTGGTGTTTGAGTGCA
TTCGAAGCCAAAAGCGTATTGCGTCGCGGCAGGGTGAGCTGCGCCTGCTGGAGAACCAACGCCTGGGTTGGCATGGGCAG
GAGTGGCAACTGCTAAAGCAGCCCTGGATGCCACGTTACGGCATTCTGTTGACCTTACAGCCGGTGGGAGGCAAAAAGCA
CCGTCGGCTGTGGCTGGCTTCCGACTCCATGGCTAAAGCCGACTGGCGGCAGTTGCGCCAACGGTTGCTGTATCCGCCCG
CCAGTGATGACGAGGAGCCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10457.96 Da
• Isoelectric Point: 4.7921

>AT122891 WP_012146600.1 NZ_CP038467:4466306-4466572 [Serratia quinivorans]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDLLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT122891 NZ_CP038467:4466306-4466572 [Serratia quinivorans]
ATGGATATTAATAACAAAGCACGTATCCACTGGGCTTGTCGCCGCGGTATGCGTGAGCTGGACATCTCCATCATGCCCTT
CTTCGAGTATGAATATGACCTGTTGAACGATACAGACAAAGCGCTGTTTATCCGTCTGCTGGAGTCTGACGATCCCGATC
TCTTCAATTGGCTGATGAATCATGGCGCTCCGCAGGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2X2H1C0