Detailed information of TA system TA122890

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4233336..4234099
• Replicon: chromosome
• Accession: NZ_CP038467
• Organism: Serratia quinivorans strain PKL:12

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: E4343_RS19855
• Protein ID: WP_135344895.1
• Coordinates: 4233336..4233704 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: E4343_RS19860
• Protein ID: WP_135344896.1
• Coordinates: 4233758..4234099 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4343_RS19825	4229055..4229378	+	324	WP_012146885.1	hypothetical protein	-
E4343_RS19830	4229443..4230324	-	882	WP_135344892.1	alpha/beta hydrolase	-
E4343_RS19835	4230658..4231227	+	570	WP_135344893.1	MepB family protein	-
E4343_RS19840	4231309..4231711	-	403	Protein_3843	DUF4102 domain-containing protein	-
E4343_RS19845	4232069..4232906	-	838	Protein_3844	DUF4942 domain-containing protein	-
E4343_RS19850	4233010..4233339	-	330	WP_135344894.1	hypothetical protein	-
E4343_RS19855	4233336..4233704	-	369	WP_135344895.1	TA system toxin CbtA family protein	Toxin
E4343_RS19860	4233758..4234099	-	342	WP_135344896.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
E4343_RS19865	4234110..4234589	-	480	WP_135345182.1	DNA repair protein RadC	-
E4343_RS19870	4234625..4235082	-	458	Protein_3849	antirestriction protein	-
E4343_RS19875	4235252..4235608	-	357	WP_135344897.1	hypothetical protein	-
E4343_RS19880	4235771..4236049	-	279	WP_189636458.1	hypothetical protein	-
E4343_RS19885	4236283..4236846	-	564	WP_135344898.1	hypothetical protein	-
E4343_RS19890	4237094..4237849	-	756	WP_135345184.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4232310..4294235	61925

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13631.72 Da
• Isoelectric Point: 9.0047

>T122890 WP_135344895.1 NZ_CP038467:c4233704-4233336 [Serratia quinivorans]
MQTVSASQKREAQPCPSPVAIWQSLLAHLLSQHYGLTLNDTAFSDDTVIRKHIDAGISLADALNCIVEKFDLVRIDRRGF
SCREQSPFVTAIDILRARQACGLMTRCGYRTITQTLQGKKRP

Nucleotide

• Length: 369 bp

>T122890 NZ_CP038467:c4233704-4233336 [Serratia quinivorans]
ATGCAAACAGTATCAGCATCCCAAAAACGGGAGGCTCAGCCCTGCCCGTCACCCGTTGCCATCTGGCAATCCTTACTCGC
ACACCTATTGTCACAGCATTACGGCCTGACCCTGAACGATACCGCGTTCAGCGATGATACCGTGATTCGAAAACACATCG
ATGCCGGCATCTCGCTCGCCGATGCGTTGAATTGTATCGTGGAAAAGTTTGACCTGGTACGCATCGACCGTCGGGGTTTC
TCCTGCCGTGAACAATCCCCTTTCGTCACCGCCATCGATATTCTGCGCGCTCGCCAGGCCTGTGGCTTGATGACCCGATG
TGGTTACCGCACCATTACGCAGACCCTCCAGGGGAAAAAGCGCCCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12630.29 Da
• Isoelectric Point: 6.8581

>AT122890 WP_135344896.1 NZ_CP038467:c4234099-4233758 [Serratia quinivorans]
MSSIEVPAWGLKRNITPQLGARLVQQGNRLYYLADRAGISGAFSEAQTRSLDTAFPQFINHLELMLLSGELNPRYQHCVT
LYRDGLTCEADSLGSHGYIYISIYPTHEAPTKN

Nucleotide

• Length: 342 bp

>AT122890 NZ_CP038467:c4234099-4233758 [Serratia quinivorans]
ATGTCTTCTATCGAAGTCCCTGCCTGGGGTCTGAAACGCAACATCACACCGCAGTTGGGTGCCCGCCTAGTGCAGCAAGG
TAACAGACTCTATTATCTGGCCGACCGTGCCGGCATCAGCGGCGCCTTCAGCGAAGCGCAGACCCGTTCACTGGATACGG
CCTTCCCGCAGTTCATCAACCATCTGGAACTGATGCTGTTGTCCGGGGAACTCAATCCTCGGTATCAGCACTGCGTCACG
CTGTACCGTGACGGATTGACGTGCGAGGCAGACAGCCTCGGATCGCACGGCTACATCTATATATCGATTTATCCGACACA
CGAAGCACCCACGAAAAACTGA