Detailed information of TA system TA122887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2535985..2536541
• Replicon: chromosome
• Accession: NZ_CP038467
• Organism: Serratia quinivorans strain PKL:12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E4343_RS11875
• Protein ID: WP_115183219.1
• Coordinates: 2536251..2536541 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X2GF13
• Locus tag: E4343_RS11870
• Protein ID: WP_012005371.1
• Coordinates: 2535985..2536263 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4343_RS11845	2531324..2532163	-	840	WP_012005376.1	MurR/RpiR family transcriptional regulator	-
E4343_RS11850	2532309..2533895	+	1587	WP_115183216.1	gamma-glutamyltransferase family protein	-
E4343_RS11855	2533921..2534112	+	192	WP_115183217.1	oxalurate catabolism protein HpxX	-
E4343_RS11860	2534109..2535509	+	1401	WP_115183218.1	AtzE family amidohydrolase	-
E4343_RS11865	2535513..2535899	+	387	WP_012005372.1	oxalurate catabolism protein HpxZ	-
E4343_RS11870	2535985..2536263	+	279	WP_012005371.1	ribbon-helix-helix protein, CopG family	Antitoxin
E4343_RS11875	2536251..2536541	+	291	WP_115183219.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4343_RS11880	2536551..2537435	-	885	WP_115183220.1	siderophore-interacting protein	-
E4343_RS11885	2537441..2538664	-	1224	WP_135344628.1	MFS transporter	-
E4343_RS11890	2538802..2540547	+	1746	WP_135344629.1	IucA/IucC family siderophore biosynthesis protein	-
E4343_RS11895	2540544..2541494	+	951	WP_135344630.1	acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10984.46 Da
• Isoelectric Point: 6.6416

>T122887 WP_115183219.1 NZ_CP038467:2536251-2536541 [Serratia quinivorans]
VPQLIWTPAALQDIQRLYRFLAEKDLNSAKRAVATIRHSVNILAHQPQVGRPVEEMDTEFREWPIDFGNSGYIVLYHFDG
HTAVLLAVRHQSEAGY

Nucleotide

• Length: 291 bp

>T122887 NZ_CP038467:2536251-2536541 [Serratia quinivorans]
GTGCCACAACTGATATGGACGCCTGCAGCGCTACAAGATATTCAGCGATTGTACCGATTTCTGGCGGAGAAAGACCTCAA
CTCCGCAAAGAGGGCCGTTGCCACCATCCGTCACAGCGTCAATATCCTCGCTCACCAACCGCAGGTAGGTCGCCCGGTTG
AAGAGATGGATACGGAATTTAGAGAATGGCCGATCGATTTCGGCAACAGTGGTTATATCGTGCTATATCATTTTGATGGC
CACACCGCAGTACTGCTGGCGGTGCGCCACCAAAGTGAAGCCGGCTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10850.09 Da
• Isoelectric Point: 5.2246

>AT122887 WP_012005371.1 NZ_CP038467:2535985-2536263 [Serratia quinivorans]
MTSATSIKIDEQLKQRVQQIAATRQRSAHWIMREAIREYVEREEKREALRKDALQAWEVYQANGKHLSQEEADNWLISLE
KGDDTEIPECHN

Nucleotide

• Length: 279 bp

>AT122887 NZ_CP038467:2535985-2536263 [Serratia quinivorans]
ATGACAAGTGCAACATCGATTAAAATTGATGAACAACTGAAGCAGCGGGTGCAGCAAATTGCGGCTACACGCCAGCGCAG
CGCGCACTGGATAATGCGCGAGGCGATCCGCGAATATGTCGAACGAGAAGAAAAACGCGAAGCGCTGCGCAAAGATGCGT
TACAGGCATGGGAAGTCTATCAGGCAAATGGTAAACATCTGTCTCAGGAAGAGGCCGATAATTGGCTCATCAGCCTGGAA
AAAGGTGATGATACGGAGATCCCGGAGTGCCACAACTGA

Structures

Antitoxin

• AlphaFold DB: A0A2X2GF13