Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2320345..2320972 Replicon chromosome
Accession NZ_CP038467
Organism Serratia quinivorans strain PKL:12

Toxin (Protein)


Gene name Hha Uniprot ID A0A2X2GU35
Locus tag E4343_RS10855 Protein ID WP_012005558.1
Coordinates 2320769..2320972 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag E4343_RS10850 Protein ID WP_004940312.1
Coordinates 2320345..2320713 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4343_RS10820 2316385..2316642 + 258 WP_012005564.1 type B 50S ribosomal protein L31 -
E4343_RS10825 2316655..2316795 + 141 WP_012005563.1 type B 50S ribosomal protein L36 -
E4343_RS10830 2316909..2317787 - 879 WP_012005562.1 metal ABC transporter substrate-binding protein -
E4343_RS10835 2317813..2318670 - 858 WP_012005561.1 metal ABC transporter permease -
E4343_RS10840 2318667..2319380 - 714 WP_135344580.1 ABC transporter ATP-binding protein -
E4343_RS10845 2319856..2320182 + 327 WP_049767909.1 hypothetical protein -
E4343_RS10850 2320345..2320713 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
E4343_RS10855 2320769..2320972 + 204 WP_012005558.1 hemolysin expression modulator Hha Toxin
E4343_RS10860 2321050..2321982 - 933 WP_012005557.1 LysR family transcriptional regulator -
E4343_RS10865 2322120..2323907 + 1788 WP_115183130.1 adenine deaminase -
E4343_RS10870 2323990..2325333 + 1344 WP_112362757.1 NCS2 family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8101.45 Da        Isoelectric Point: 6.9770

>T122886 WP_012005558.1 NZ_CP038467:2320769-2320972 [Serratia quinivorans]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 204 bp

>T122886 NZ_CP038467:2320769-2320972 [Serratia quinivorans]
ATGACTAAAATTGATTATCTGATGCGTTTACGTAAATGCACCACGATCGAAACACTGGAACGCGTTATTGAAAAAAACAA
GTATGAGCTTTCAGATGACGAACTGGAGCTGTTTTACTCTGCAGCCGACCATCGCCTGGCCGAGCTCACCATGAATAAAC
TCTACGATAAAATCCCTACTGCCGTTTGGAAATTCGTAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT122886 WP_004940312.1 NZ_CP038467:2320345-2320713 [Serratia quinivorans]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT122886 NZ_CP038467:2320345-2320713 [Serratia quinivorans]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTGAAATTCTTGTGTGAAAACCTGTATGATGAAGGTATCGC
CACGCTGGGCGACAGCCATCATGGCTGGGTGAACGATCCGACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAACTTGTCGAAGAGTATCTC
GATGATACCTACACGCTGTTCAGCAGTTACGGTATAAATGATTCCGATCTGCGTCGTTGGCAGAAAACCAAGGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2GU35

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References