Detailed information of TA system TA122885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1822670..1823223
• Replicon: chromosome
• Accession: NZ_CP038467
• Organism: Serratia quinivorans strain PKL:12

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: E4343_RS08365
• Protein ID: WP_012005988.1
• Coordinates: 1822670..1822984 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A379YKU0
• Locus tag: E4343_RS08370
• Protein ID: WP_012005987.1
• Coordinates: 1822987..1823223 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4343_RS08345	1818441..1819598	-	1158	WP_012005992.1	YbfB/YjiJ family MFS transporter	-
E4343_RS08350	1819705..1820622	+	918	WP_017892162.1	LysR family transcriptional regulator	-
E4343_RS08355	1820649..1821776	+	1128	WP_012005990.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
E4343_RS08360	1821791..1822633	+	843	WP_017892161.1	S-formylglutathione hydrolase	-
E4343_RS08365	1822670..1822984	-	315	WP_012005988.1	CcdB family protein	Toxin
E4343_RS08370	1822987..1823223	-	237	WP_012005987.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
E4343_RS08375	1823822..1824730	-	909	WP_172491122.1	glutathione ABC transporter permease GsiD	-
E4343_RS08380	1824740..1825660	-	921	WP_017892158.1	glutathione ABC transporter permease GsiC	-
E4343_RS08385	1825711..1827249	-	1539	WP_135344475.1	glutathione ABC transporter substrate-binding protein GsiB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11637.58 Da
• Isoelectric Point: 5.0772

>T122885 WP_012005988.1 NZ_CP038467:c1822984-1822670 [Serratia quinivorans]
MQFTVYANTGKSTVYPLLLDVTSDIIGQLNRRVVIPLLPIEKFPGSTRPERLIPLVRLVDDKEYAVMTHEMASIPVRALG
AEFCDATQYRTEVKAAIDFLLDGI

Nucleotide

• Length: 315 bp

>T122885 NZ_CP038467:c1822984-1822670 [Serratia quinivorans]
ATGCAATTTACGGTATACGCAAATACAGGGAAAAGTACTGTTTACCCGCTGCTGCTTGATGTGACGAGCGATATCATCGG
GCAATTAAATCGTCGAGTCGTGATCCCGTTATTGCCCATTGAAAAGTTTCCGGGTAGCACTCGCCCGGAACGTTTGATCC
CTTTGGTCAGGCTGGTGGATGACAAGGAGTACGCCGTTATGACACATGAGATGGCAAGTATTCCCGTTCGGGCCTTGGGT
GCTGAATTTTGCGATGCTACCCAATACCGGACCGAGGTTAAAGCCGCAATAGATTTTCTTCTCGACGGTATCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9108.19 Da
• Isoelectric Point: 6.7184

>AT122885 WP_012005987.1 NZ_CP038467:c1823223-1822987 [Serratia quinivorans]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEDNREAIEALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT122885 NZ_CP038467:c1823223-1822987 [Serratia quinivorans]
ATGCCAGTAAAACAACGAACGACGCAAAGCGTTACCATGACGGTAGAACGCAGCTTGTTGAGCCGTGCACGTGAGGCGGG
TATTAACCTCAGTGCTACGCTGAACGCTGCTTTGGATGCCGAATTGCGTCAGCATGAGATGAGAAAATGGAAGGAAGATA
ACCGAGAGGCCATTGAGGCGCTGAACCGTTTTCATGATGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Structures

Antitoxin

• AlphaFold DB: A0A379YKU0