Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 286331..286958 Replicon chromosome
Accession NZ_CP038467
Organism Serratia quinivorans strain PKL:12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E4343_RS01370 Protein ID WP_012145654.1
Coordinates 286776..286958 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E4343_RS01365 Protein ID WP_012145655.1
Coordinates 286331..286744 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4343_RS01335 281558..282280 + 723 WP_012145661.1 RNA polymerase sigma factor FliA -
E4343_RS01340 282338..282847 + 510 WP_012145660.1 flagella biosynthesis regulatory protein FliZ -
E4343_RS01345 282975..283967 + 993 WP_135344172.1 D-cysteine desulfhydrase -
E4343_RS01350 284082..284882 + 801 WP_135344173.1 cystine ABC transporter substrate-binding protein -
E4343_RS01355 284882..285543 + 662 Protein_263 cystine ABC transporter permease -
E4343_RS01360 285547..286299 + 753 WP_012145656.1 L-cystine ABC transporter ATP-binding protein YecC -
E4343_RS01365 286331..286744 - 414 WP_012145655.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4343_RS01370 286776..286958 - 183 WP_012145654.1 type II toxin-antitoxin system HicA family toxin Toxin
E4343_RS01375 287125..291096 - 3972 WP_135344174.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6819.00 Da        Isoelectric Point: 11.0468

>T122875 WP_012145654.1 NZ_CP038467:c286958-286776 [Serratia quinivorans]
VKSSELIGLLEQEGWVLERIKGSHHQFKHPGSRLVITVPHPRKDLKPGTLRQIMKDAGLR

Download         Length: 183 bp

>T122875 NZ_CP038467:c286958-286776 [Serratia quinivorans]
GTGAAAAGTTCAGAACTGATTGGGCTATTAGAACAGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACACCCAGGATCCCGCCTGGTGATCACCGTTCCACACCCGCGTAAGGATCTTAAACCGGGAACGCTGCGCCAAATCA
TGAAAGATGCCGGACTGCGCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15153.78 Da        Isoelectric Point: 4.7041

>AT122875 WP_012145655.1 NZ_CP038467:c286744-286331 [Serratia quinivorans]
MFYPAYVHSEHDGSASGFFPDVPGCYFAGDTLDRAFEDAKSALDAHFELLSEDNQSIPRPQAVSFHLAQESDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSMVQQHPGYGSRSAFLAAAARNELLNAG

Download         Length: 414 bp

>AT122875 NZ_CP038467:c286744-286331 [Serratia quinivorans]
ATGTTCTACCCTGCTTATGTACATTCAGAACACGACGGCAGCGCCAGCGGTTTCTTTCCCGATGTGCCGGGCTGCTATTT
TGCAGGCGATACCCTCGATAGAGCCTTTGAAGACGCCAAAAGCGCGCTGGACGCACATTTCGAACTTCTGAGCGAAGACA
ACCAGTCCATCCCACGCCCACAGGCCGTTTCCTTCCATCTGGCGCAGGAGAGCGACACGCTGAATGGCGGACAGTGGCTG
CTGGTCGACATCAATATGGATAAGTTTGACGGTCGGGCTGAACGTATCAATATTACCCTGCCGCACCGCCTGCTGAACCG
TATCGATTCAATGGTACAGCAGCATCCGGGCTATGGTAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTAT
TGAACGCTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References