Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2110913..2111427 Replicon chromosome
Accession NZ_CP038461
Organism Staphylococcus aureus strain O217

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag SaO217_RS10240 Protein ID WP_000581791.1
Coordinates 2110913..2111122 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag SaO217_RS10245 Protein ID WP_000138934.1
Coordinates 2111134..2111427 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO217_RS10220 2106802..2107872 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
SaO217_RS10225 2108190..2109392 + 1203 WP_029550322.1 rod shape-determining protein RodA -
SaO217_RS10230 2109553..2110236 - 684 Protein_1978 transposase -
SaO217_RS10235 2110648..2110785 - 138 WP_000828354.1 hypothetical protein -
SaO217_RS10240 2110913..2111122 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
SaO217_RS10245 2111134..2111427 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
SaO217_RS10250 2111593..2113077 + 1485 WP_000571560.1 cardiolipin synthase -
SaO217_RS10255 2113105..2113752 + 648 WP_001187612.1 HD domain-containing protein -
SaO217_RS10260 2113909..2114208 + 300 WP_001793952.1 hypothetical protein -
SaO217_RS10265 2114365..2115237 - 873 WP_000725802.1 membrane protein insertase YidC -
SaO217_RS10270 2115323..2115964 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T122866 WP_000581791.1 NZ_CP038461:c2111122-2110913 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T122866 NZ_CP038461:c2111122-2110913 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT122866 WP_000138934.1 NZ_CP038461:c2111427-2111134 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT122866 NZ_CP038461:c2111427-2111134 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References