122860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 855175..855652 Replicon chromosome
Accession NZ_CP038461
Organism Staphylococcus aureus strain O217

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SaO217_RS04095 Protein ID WP_000052076.1
Coordinates 855175..855363 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SaO217_RS04100 Protein ID WP_001059690.1
Coordinates 855392..855652 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO217_RS04065 851128..851685 + 558 WP_000824491.1 hypothetical protein -
SaO217_RS04070 852026..852712 + 687 WP_199878686.1 thermonuclease family protein -
SaO217_RS04075 853069..853269 + 201 WP_001059082.1 cold-shock protein -
SaO217_RS04080 853766..853984 - 219 WP_000005879.1 hypothetical protein -
SaO217_RS04085 854046..854330 - 285 WP_001004401.1 hypothetical protein -
SaO217_RS04090 854418..854987 - 570 WP_001106663.1 hypothetical protein -
SaO217_RS04095 855175..855363 - 189 WP_000052076.1 hypothetical protein Toxin
SaO217_RS04100 855392..855652 - 261 WP_001059690.1 hypothetical protein Antitoxin
SaO217_RS04105 855993..856196 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SaO217_RS04110 856193..856429 - 237 WP_000368687.1 hypothetical protein -
SaO217_RS04115 856654..857235 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SaO217_RS04120 857308..857925 - 618 WP_199878687.1 LysE/ArgO family amino acid transporter -
SaO217_RS04125 858287..858781 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SaO217_RS04130 859180..859602 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SaO217_RS04135 859750..860466 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Antitoxin MqsA/HigA-2

(28-101)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T122860 WP_000052076.1 NZ_CP038461:c855363-855175 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T122860 NZ_CP038461:c855363-855175 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT122860 WP_001059690.1 NZ_CP038461:c855652-855392 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT122860 NZ_CP038461:c855652-855392 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References