122845

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 844567..845044 Replicon chromosome
Accession NZ_CP038460
Organism Staphylococcus aureus strain B119

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SaO322_RS04260 Protein ID WP_000052076.1
Coordinates 844567..844755 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SaO322_RS04265 Protein ID WP_001059690.1
Coordinates 844784..845044 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO322_RS04225 840297..840818 + 522 WP_000824478.1 hypothetical protein -
SaO322_RS04230 841159..841845 + 687 WP_001641381.1 thermonuclease family protein -
SaO322_RS04235 842202..842402 + 201 WP_001059082.1 cold-shock protein -
SaO322_RS04245 843158..843376 - 219 WP_000005880.1 hypothetical protein -
SaO322_RS04250 843438..843722 - 285 WP_001004402.1 hypothetical protein -
SaO322_RS04255 843810..844379 - 570 WP_001106650.1 hypothetical protein -
SaO322_RS04260 844567..844755 - 189 WP_000052076.1 hypothetical protein Toxin
SaO322_RS04265 844784..845044 - 261 WP_001059690.1 hypothetical protein Antitoxin
SaO322_RS04270 845385..845588 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SaO322_RS04275 845585..845821 - 237 WP_000368687.1 hypothetical protein -
SaO322_RS04280 846046..846627 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SaO322_RS04285 846700..847317 - 618 WP_118848075.1 LysE/ArgO family amino acid transporter -
SaO322_RS04290 847473..847967 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SaO322_RS04295 848366..848788 - 423 WP_000974462.1 organic hydroperoxide resistance protein -
SaO322_RS04300 848936..849652 + 717 WP_000150023.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T122845 WP_000052076.1 NZ_CP038460:c844755-844567 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T122845 NZ_CP038460:c844755-844567 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT122845 WP_001059690.1 NZ_CP038460:c845044-844784 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT122845 NZ_CP038460:c845044-844784 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References