Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 321833..322636 Replicon chromosome
Accession NZ_CP038460
Organism Staphylococcus aureus strain B119

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag SaO322_RS01460 Protein ID WP_118848034.1
Coordinates 321833..322294 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag SaO322_RS01465 Protein ID WP_001573842.1
Coordinates 322307..322636 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO322_RS01435 318779..319984 - 1206 WP_065316550.1 site-specific integrase -
SaO322_RS01440 320112..320726 + 615 WP_065316551.1 ATPase -
SaO322_RS01445 320723..320869 - 147 WP_001013104.1 hypothetical protein -
SaO322_RS01450 320958..321353 - 396 WP_001558060.1 hypothetical protein -
SaO322_RS01455 321381..321815 - 435 WP_118848033.1 hypothetical protein -
SaO322_RS01460 321833..322294 - 462 WP_118848034.1 toxin Toxin
SaO322_RS01465 322307..322636 - 330 WP_001573842.1 helix-turn-helix domain-containing protein Antitoxin
SaO322_RS01470 322828..323073 + 246 WP_065316554.1 helix-turn-helix domain-containing protein -
SaO322_RS14250 323087..323263 + 177 WP_015994739.1 hypothetical protein -
SaO322_RS01475 323260..323490 - 231 WP_000549548.1 hypothetical protein -
SaO322_RS01480 323545..323832 + 288 WP_065316727.1 hypothetical protein -
SaO322_RS01485 323780..324022 - 243 WP_000498529.1 hypothetical protein -
SaO322_RS01490 324082..324297 + 216 WP_001097552.1 hypothetical protein -
SaO322_RS01495 324322..324585 + 264 WP_118848035.1 helix-turn-helix domain-containing protein -
SaO322_RS01500 324598..324765 + 168 WP_118848036.1 DUF1270 domain-containing protein -
SaO322_RS01505 324766..325086 + 321 WP_000219664.1 hypothetical protein -
SaO322_RS01510 325180..325368 + 189 Protein_285 DUF1108 family protein -
SaO322_RS01515 325362..325463 + 102 Protein_286 DUF3269 family protein -
SaO322_RS01520 325474..325878 + 405 WP_000049813.1 DUF1064 domain-containing protein -
SaO322_RS01525 325883..326068 + 186 WP_065315894.1 DUF3113 family protein -
SaO322_RS01530 326069..326326 + 258 WP_000772917.1 helix-turn-helix transcriptional regulator -
SaO322_RS01535 326338..326709 + 372 WP_001140276.1 hypothetical protein -
SaO322_RS01540 326710..326958 + 249 WP_001124144.1 phi PVL orf 51-like protein -
SaO322_RS01545 326972..327178 + 207 WP_000693996.1 hypothetical protein -
SaO322_RS01550 327181..327591 + 411 WP_000695751.1 DUF4388 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 318779..355308 36529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17899.27 Da        Isoelectric Point: 4.6696

>T122841 WP_118848034.1 NZ_CP038460:c322294-321833 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILLEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLGVFKYKEI

Download         Length: 462 bp

>T122841 NZ_CP038460:c322294-321833 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTAGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAGTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCAGTCCCGTTACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCTATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGGGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12730.33 Da        Isoelectric Point: 6.4836

>AT122841 WP_001573842.1 NZ_CP038460:c322636-322307 [Staphylococcus aureus]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEEPQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT122841 NZ_CP038460:c322636-322307 [Staphylococcus aureus]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCTCTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATAGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAAGAACCACAGCAC
CGTGCAGCTCATTTAGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAA
ACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References