Detailed information of TA system TA122802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 4606791..4607368
• Replicon: chromosome
• Accession: NZ_CP038443
• Organism: Aeromonas media strain R1-18

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: E4185_RS21480
• Protein ID: WP_171274181.1
• Coordinates: 4606970..4607368 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A6M4YTF0
• Locus tag: E4185_RS21475
• Protein ID: WP_033137226.1
• Coordinates: 4606791..4606970 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4185_RS21450	4602685..4604022	+	1338	WP_041206764.1	IS4-like element ISAeme15 family transposase	-
E4185_RS21455	4604444..4605262	-	819	WP_171274177.1	KilA-N domain-containing protein	-
E4185_RS21460	4605341..4605505	-	165	WP_171274178.1	Arc family DNA-binding protein	-
E4185_RS21465	4605654..4606010	+	357	WP_171274179.1	Arc family DNA-binding protein	-
E4185_RS21470	4606086..4606433	+	348	WP_171274180.1	hypothetical protein	-
E4185_RS21475	4606791..4606970	+	180	WP_033137226.1	hypothetical protein	Antitoxin
E4185_RS21480	4606970..4607368	+	399	WP_171274181.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4604444..4685097	80653
	-	flank	IS/Tn	-	-	4602685..4604022	1337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (47-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14465.49 Da
• Isoelectric Point: 4.1179

>T122802 WP_171274181.1 NZ_CP038443:4606970-4607368 [Aeromonas media]
MDIIQFPPARVLEINHYILGASPGHQGPASIALLEGALGRIDNAIAYSGLNDVFLIAAKYAMAIGTAHAFSDANKRTGLA
VCLEYLSLNDFEIERDNEKLADAMVDLVLGELPEEWFADILYALWLEEQKTS

Nucleotide

• Length: 399 bp

>T122802 NZ_CP038443:4606970-4607368 [Aeromonas media]
ATGGATATCATCCAGTTTCCTCCCGCTCGGGTGCTGGAGATTAACCACTACATCCTAGGTGCGTCGCCTGGTCATCAGGG
CCCTGCCAGCATCGCGTTATTGGAGGGGGCGCTTGGCCGCATCGACAACGCCATCGCCTACAGCGGGCTAAACGATGTGT
TTCTCATCGCAGCAAAGTACGCAATGGCCATCGGTACCGCTCACGCCTTTTCCGATGCCAATAAGCGCACCGGACTCGCG
GTCTGCCTTGAGTATCTCTCCCTCAACGACTTCGAGATTGAAAGAGATAACGAGAAGCTGGCGGACGCTATGGTTGACCT
TGTGCTTGGCGAGCTGCCAGAAGAGTGGTTTGCCGATATCCTTTACGCGCTTTGGTTGGAAGAGCAAAAAACCTCCTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6788.82 Da
• Isoelectric Point: 10.1555

>AT122802 WP_033137226.1 NZ_CP038443:4606791-4606970 [Aeromonas media]
MKDNTVSNKYGLPQVQNRPQIKAEKNLCLNGEEGRQIIKSETKLTLKTHEKTFTRLADM

Nucleotide

• Length: 180 bp

>AT122802 NZ_CP038443:4606791-4606970 [Aeromonas media]
ATGAAAGACAACACCGTCAGCAACAAATATGGATTGCCACAAGTGCAGAATCGGCCACAAATCAAGGCTGAAAAGAACCT
GTGCCTGAACGGTGAAGAGGGCCGCCAGATCATCAAGTCTGAGACCAAGCTGACACTGAAGACCCACGAGAAGACCTTCA
CCCGTTTGGCTGATATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6M4YTF0