Detailed information of TA system TA122800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4852921..4854494
• Replicon: chromosome
• Accession: NZ_CP038441
• Organism: Aeromonas media strain T0.1-19

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: E4184_RS22575
• Protein ID: WP_171277152.1
• Coordinates: 4852921..4854240 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3Q8DTG9
• Locus tag: E4184_RS22580
• Protein ID: WP_042047685.1
• Coordinates: 4854240..4854494 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4184_RS22560	4848980..4849744	+	765	WP_171277150.1	ATP-binding cassette domain-containing protein	-
E4184_RS22565	4849719..4850675	+	957	WP_171277296.1	ABC transporter substrate-binding protein	-
E4184_RS22570	4850672..4852654	+	1983	WP_171277151.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
E4184_RS22575	4852921..4854240	-	1320	WP_171277152.1	type II toxin-antitoxin system HipA family toxin	Toxin
E4184_RS22580	4854240..4854494	-	255	WP_042047685.1	helix-turn-helix domain-containing protein	Antitoxin
E4184_RS22585	4855033..4855656	+	624	WP_042878565.1	recombinase family protein	-
E4184_RS22590	4856424..4858889	+	2466	WP_103243989.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49480.49 Da
• Isoelectric Point: 6.8288

>T122800 WP_171277152.1 NZ_CP038441:c4854240-4852921 [Aeromonas media]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDVKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFDRSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSAILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T122800 NZ_CP038441:c4854240-4852921 [Aeromonas media]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCCTGGCTGGCACAACCAGGCAGCCGTCCCATCTCACTCTCTATGCCATTGCGCCATCAGCCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACACAGCCCTTCGATCTGCTCAGTTGCATTGGCCAAGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATAATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGATCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
TCGAAGGGACGTCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGCC
ATTTCTTCCAAACTGCGAAAGCTGTGGGATTTGATCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTGACCCAGCAATTGCCGGCAGGCTTTCCCGATACCATCAGCAGCGCCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT122800 WP_042047685.1 NZ_CP038441:c4854494-4854240 [Aeromonas media]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT122800 NZ_CP038441:c4854494-4854240 [Aeromonas media]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAACCCTGAGTCCACCAAGCTGGAGACCCTGT
TCAAGATCCTCGCGGCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGATAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Q8DTG9