Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 1857906..1859620 Replicon chromosome
Accession NZ_CP038441
Organism Aeromonas media strain T0.1-19

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag E4184_RS08685 Protein ID WP_171275904.1
Coordinates 1857906..1858559 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag E4184_RS08690 Protein ID WP_171277217.1
Coordinates 1858556..1859620 (+) Length 355 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4184_RS08665 1852999..1853187 + 189 WP_021138010.1 DUF3283 family protein -
E4184_RS08670 1853334..1853780 + 447 WP_043852095.1 hypothetical protein -
E4184_RS08675 1853967..1856414 + 2448 WP_171275902.1 type I restriction-modification system subunit M -
E4184_RS08680 1856414..1857640 + 1227 WP_171275903.1 restriction endonuclease subunit S -
E4184_RS08685 1857906..1858559 + 654 WP_171275904.1 DUF4433 domain-containing protein Toxin
E4184_RS08690 1858556..1859620 + 1065 WP_171277217.1 macro domain-containing protein Antitoxin
E4184_RS08695 1859695..1862826 + 3132 WP_171275905.1 HsdR family type I site-specific deoxyribonuclease -
E4184_RS08700 1862826..1863539 + 714 WP_005331303.1 M48 family metallopeptidase -
E4184_RS08705 1863558..1864495 - 938 Protein_1658 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-216)

Antitoxin

Macro domain

(18-131)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 25304.86 Da        Isoelectric Point: 6.8260

>T122798 WP_171275904.1 NZ_CP038441:1857906-1858559 [Aeromonas media]
MAYDYSQSLNPQKALIFRIVHRDNLEWILTHGLWAGNGQQQNPHWVHIGLPELIAKRARHPVPLAPYGVLNDYVPFYFTP
FSPMLSNIHSGRGVPQRENDEILILVSSLHRMAELGLPFVFTDSHAYYQWANFYVDLGDLGRIDWPLLQRRDFKRDAEDL
SKLERYQAEALIHQHCPIEALLGVVCYNEEIKNSVEQCMNRVGVSRPVYVRDGWYFR

Download         Length: 654 bp

>T122798 NZ_CP038441:1857906-1858559 [Aeromonas media]
ATGGCCTATGACTATAGCCAGAGCCTGAATCCGCAGAAGGCGCTGATATTCCGGATTGTGCATCGGGATAACCTGGAATG
GATCCTGACCCATGGCCTGTGGGCGGGGAATGGTCAGCAGCAAAACCCGCACTGGGTGCATATCGGGTTGCCGGAGCTGA
TTGCCAAGCGCGCACGCCATCCGGTGCCGCTGGCGCCTTACGGCGTGTTGAATGACTATGTGCCCTTCTACTTCACGCCG
TTTTCGCCCATGCTCAGCAATATTCACTCGGGGCGCGGTGTTCCCCAGCGTGAAAATGATGAAATCCTGATCCTGGTTTC
CAGCCTGCATCGCATGGCTGAATTGGGGCTACCGTTTGTGTTTACCGATAGCCATGCCTATTACCAGTGGGCCAATTTCT
ATGTCGACCTTGGCGATCTGGGGCGGATTGACTGGCCACTGTTGCAGCGCCGTGACTTCAAGCGTGATGCGGAAGATTTG
AGCAAGCTGGAACGCTATCAGGCCGAGGCCTTGATCCATCAACATTGCCCCATCGAGGCGTTGCTGGGCGTGGTGTGTTA
CAACGAAGAAATAAAGAACAGCGTGGAACAATGCATGAATCGGGTGGGGGTCTCGCGCCCCGTCTATGTCCGTGATGGGT
GGTATTTCAGATGA

Antitoxin


Download         Length: 355 a.a.        Molecular weight: 39606.74 Da        Isoelectric Point: 6.4996

>AT122798 WP_171277217.1 NZ_CP038441:1858556-1859620 [Aeromonas media]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPANMRAYAEACKQGDVVTGKMFITQTGELLGPRWIVNFPTK
QHWRNPAQMAWIQDGLQDLRAWLQAQQVSSIAIPPLGAGNGGLPWPEVKQAIETALGDLDIDILLYEPSSQYQNVAKRGG
VAELTPARALIAELVRRYWFLGMECSLLEIQKLAWFLARVIGRNPLGDPLQLQFKAHRYGPYANNLTHLLNAMDGSYLQS
DKRIPDSKPFDVIWFNEAKKQELAVYLNTEAKAFLPILEQTTALIDGFESPYGMELLATVDWLMVEEGCAPTLSALREGL
HRWPAGTPWGDRKARLFDDRSLQIALTRLQQGLV

Download         Length: 1065 bp

>AT122798 NZ_CP038441:1858556-1859620 [Aeromonas media]
ATGATTCGATATACAACAGGCAACCTGCTGGATGCTCCGGTGGAAGCACTGGTGAATACCGTCAACACAGTCGGTGTCAT
GGGCAAGGGGATCGCCTTGATGTTCAAGGAGCGGTTCCCGGCCAATATGCGTGCCTATGCCGAGGCGTGCAAGCAGGGTG
ACGTCGTCACCGGCAAGATGTTTATTACCCAGACGGGTGAGCTGCTAGGGCCGCGCTGGATCGTCAACTTTCCGACCAAA
CAGCACTGGCGCAATCCGGCACAGATGGCGTGGATCCAGGACGGTTTGCAGGATCTGCGGGCCTGGTTACAGGCGCAGCA
GGTCTCCTCGATTGCCATTCCACCACTGGGGGCTGGCAACGGTGGTCTGCCTTGGCCGGAGGTCAAACAGGCGATCGAAA
CGGCACTGGGCGATCTGGATATCGATATCCTGCTCTATGAGCCCAGTAGCCAATACCAAAATGTGGCCAAGCGCGGCGGG
GTGGCGGAGCTGACTCCGGCCCGGGCCCTGATTGCTGAACTGGTGCGTCGCTACTGGTTTTTAGGGATGGAGTGCAGCTT
GCTGGAGATCCAGAAACTGGCCTGGTTTCTGGCTCGGGTCATTGGCCGTAACCCGCTGGGGGATCCGCTGCAGTTGCAGT
TTAAGGCCCATCGTTATGGCCCTTATGCCAACAATCTGACCCATCTGCTCAATGCGATGGACGGCAGTTATCTGCAGTCC
GACAAGCGCATCCCGGATAGCAAGCCGTTTGATGTCATCTGGTTTAATGAGGCTAAAAAACAAGAGCTTGCCGTTTATCT
CAATACCGAGGCCAAAGCATTTTTACCGATACTGGAGCAGACGACCGCGTTAATCGATGGTTTTGAGTCGCCCTATGGCA
TGGAGTTATTGGCCACGGTGGACTGGCTGATGGTCGAAGAGGGCTGTGCGCCGACACTGAGCGCGCTGCGCGAGGGGTTG
CACCGCTGGCCAGCGGGAACCCCGTGGGGTGATCGCAAGGCGCGGCTGTTTGATGATCGCAGCCTGCAGATCGCCTTGAC
CCGTTTGCAGCAGGGATTGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References