Detailed information of TA system TA122794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3344108..3344627
• Replicon: chromosome
• Accession: NZ_CP038438
• Organism: Pseudomonas fluorescens strain LBUM677

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4T63_RS15280
• Protein ID: WP_098964185.1
• Coordinates: 3344108..3344389 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2R7MVA5
• Locus tag: E4T63_RS15285
• Protein ID: WP_003225462.1
• Coordinates: 3344379..3344627 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4T63_RS15250	3339397..3340161	-	765	WP_027612656.1	IclR family transcriptional regulator	-
E4T63_RS15255	3340374..3340763	-	390	WP_007912330.1	RidA family protein	-
E4T63_RS15260	3340794..3341591	-	798	WP_007965123.1	amino acid ABC transporter ATP-binding protein	-
E4T63_RS15265	3341588..3342250	-	663	WP_007965124.1	amino acid ABC transporter permease	-
E4T63_RS15270	3342260..3342922	-	663	WP_003225455.1	amino acid ABC transporter permease	-
E4T63_RS15275	3342973..3343821	-	849	WP_098964184.1	transporter substrate-binding domain-containing protein	-
E4T63_RS15280	3344108..3344389	-	282	WP_098964185.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4T63_RS15285	3344379..3344627	-	249	WP_003225462.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E4T63_RS15290	3344904..3345332	+	429	WP_135295911.1	thioredoxin family protein	-
E4T63_RS15295	3345499..3347058	-	1560	WP_135295912.1	TerC family protein	-
E4T63_RS15300	3347474..3349120	-	1647	WP_135295913.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10911.69 Da
• Isoelectric Point: 10.6783

>T122794 WP_098964185.1 NZ_CP038438:c3344389-3344108 [Pseudomonas fluorescens]
MTYELEFSEKAWREWRKLDSALQDQFKKKLSTRLVNPHVPADRLRGLGNAYKIKLRSAGYRLVYRVKNEVLVVTVIAVGR
RERGEVYDKAACR

Nucleotide

• Length: 282 bp

>T122794 NZ_CP038438:c3344389-3344108 [Pseudomonas fluorescens]
ATGACCTATGAGCTGGAGTTTTCCGAGAAAGCCTGGAGGGAATGGAGAAAGCTTGATTCAGCACTTCAGGATCAGTTCAA
GAAAAAGCTCTCTACACGTCTGGTCAATCCTCACGTTCCTGCCGATCGACTCCGAGGGTTGGGAAACGCCTACAAAATCA
AGCTTCGCAGTGCTGGATACAGGCTGGTCTATCGCGTAAAGAACGAGGTTTTGGTTGTTACCGTGATTGCGGTAGGGAGA
AGAGAGCGGGGAGAGGTCTACGACAAAGCCGCTTGCCGATAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9005.38 Da
• Isoelectric Point: 4.5338

>AT122794 WP_003225462.1 NZ_CP038438:c3344627-3344379 [Pseudomonas fluorescens]
MTHVVLSNIVASISELKRNPMGTVAAGGGQSVAILNRNEPAFYCVPAKEYEAMMNRLEDLELIALCKERENDPTIKVSID
DL

Nucleotide

• Length: 249 bp

>AT122794 NZ_CP038438:c3344627-3344379 [Pseudomonas fluorescens]
ATGACTCACGTAGTTCTTTCCAATATCGTTGCGAGTATTTCTGAATTGAAAAGAAACCCCATGGGTACCGTGGCCGCCGG
TGGCGGCCAATCTGTTGCAATCCTCAATCGAAATGAGCCAGCGTTTTATTGTGTTCCCGCAAAGGAGTATGAGGCGATGA
TGAATCGCCTTGAGGATCTGGAACTGATCGCACTGTGCAAGGAGCGAGAAAACGATCCCACCATCAAGGTCTCTATAGAT
GACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A2R7MVA5