Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2776988..2778213 Replicon chromosome
Accession NZ_CP038438
Organism Pseudomonas fluorescens strain LBUM677

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4T63_RS12515 Protein ID WP_135295602.1
Coordinates 2776988..2777578 (-) Length 197 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4T63_RS12520 Protein ID WP_134786184.1
Coordinates 2777656..2778213 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4T63_RS12490 2772771..2773544 + 774 WP_135295599.1 AraC family transcriptional regulator -
E4T63_RS12495 2773555..2774322 - 768 WP_003224391.1 phosphonate ABC transporter, permease protein PhnE -
E4T63_RS12500 2774319..2775146 - 828 WP_135295600.1 ABC transporter permease subunit -
E4T63_RS12505 2775140..2775937 - 798 WP_135295601.1 ATP-binding cassette domain-containing protein -
E4T63_RS12510 2775934..2776797 - 864 WP_096796864.1 putative selenate ABC transporter substrate-binding protein -
E4T63_RS12515 2776988..2777578 - 591 WP_135295602.1 HD domain-containing protein Toxin
E4T63_RS12520 2777656..2778213 - 558 WP_134786184.1 helix-turn-helix domain-containing protein Antitoxin
E4T63_RS12525 2778289..2778687 - 399 WP_135295603.1 RidA family protein -
E4T63_RS12530 2778810..2779754 + 945 WP_135295604.1 LysR family transcriptional regulator -
E4T63_RS12535 2779829..2780989 + 1161 WP_135295605.1 radical SAM protein -
E4T63_RS12540 2780971..2781858 - 888 WP_135295606.1 LysR family transcriptional regulator -
E4T63_RS12545 2781994..2783046 + 1053 WP_135295607.1 agmatine deiminase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-46)


Sequences

Toxin        


Download         Length: 197 a.a.        Molecular weight: 21896.71 Da        Isoelectric Point: 4.5781

>T122793 WP_135295602.1 NZ_CP038438:c2777578-2776988 [Pseudomonas fluorescens]
MNLEMIKGRLEFLREAEKLKDVLRSARTSSGRTESTAEHSWRLCLMAIVFADQLAGLDLLKVLKMCVIHDLGEAINGDIP
AINQAAFPDKGEQERNDLLLLTGALDEALRSEILALWDDYENAQSAEAKAVKALDKLETLLQHNQGLNPADFDYGFNLGY
GKKYTSADPVFATLRELIDQDTRQRISDGQNSNERS

Download         Length: 591 bp

>T122793 NZ_CP038438:c2777578-2776988 [Pseudomonas fluorescens]
ATGAACCTCGAAATGATCAAAGGCCGCCTCGAATTCCTGCGCGAAGCAGAAAAACTCAAGGACGTGCTGCGCAGCGCGCG
CACCTCCAGCGGCCGCACCGAAAGCACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCGATTGTCTTCGCCGATCAAC
TGGCCGGCCTCGACCTGCTCAAAGTCCTGAAGATGTGCGTGATTCACGATTTGGGCGAAGCCATCAATGGCGATATTCCG
GCGATCAATCAGGCCGCGTTCCCCGACAAGGGTGAACAGGAACGCAACGACCTTCTGCTGCTGACCGGTGCGCTCGATGA
GGCGCTGCGCAGCGAAATTCTGGCGCTGTGGGACGACTACGAAAATGCTCAGTCCGCCGAAGCCAAAGCGGTCAAGGCAC
TGGATAAACTGGAGACGCTGCTGCAACACAACCAGGGGCTGAACCCGGCGGATTTCGATTACGGTTTCAATCTGGGCTAC
GGTAAGAAATACACCAGTGCCGACCCGGTCTTCGCCACCCTGCGTGAGCTGATCGACCAAGACACGCGACAGCGCATCAG
CGACGGCCAAAACAGCAACGAGCGATCTTGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20444.63 Da        Isoelectric Point: 10.6088

>AT122793 WP_134786184.1 NZ_CP038438:c2778213-2777656 [Pseudomonas fluorescens]
MSDLLLKPALPGIALRRWRLLHRVKQTHAAQLFNVTQSTISRWESGVQAMEPAAQLQLERLLTARLDSAADQVLARLIGE
SQRPMHLICDLTHRLLACSPARAAEFTRPLSTLLGQSLWRFATPEIVLRESALATSGWHEVQAPPAVEFSTGSNASDLVP
IRAGRCRWTRIPLSDGSAARLVETL

Download         Length: 558 bp

>AT122793 NZ_CP038438:c2778213-2777656 [Pseudomonas fluorescens]
ATGTCAGACCTGTTATTGAAGCCCGCCCTGCCCGGTATCGCCCTGCGACGCTGGCGCCTGCTGCATCGCGTCAAACAGAC
TCACGCGGCGCAGTTGTTCAACGTCACCCAGTCGACCATTTCCCGCTGGGAAAGCGGTGTGCAGGCGATGGAACCTGCCG
CGCAACTGCAACTGGAGCGTTTGCTGACTGCGCGCCTGGACAGCGCCGCCGATCAGGTATTGGCGCGTCTGATCGGGGAA
AGTCAGCGGCCGATGCACCTGATCTGCGACCTCACCCATCGCCTGCTGGCCTGCTCTCCTGCGCGTGCTGCCGAGTTCAC
CCGACCCTTGAGTACGTTGCTGGGACAATCGCTGTGGCGCTTCGCAACGCCGGAAATTGTGCTGAGAGAGTCGGCCCTGG
CAACCAGCGGTTGGCACGAAGTTCAGGCGCCGCCAGCCGTGGAATTCAGCACCGGCAGCAATGCCTCCGACCTCGTGCCG
ATCCGCGCCGGCCGATGCCGCTGGACGCGCATTCCACTCTCCGACGGCAGCGCCGCGCGTCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References