Detailed information of TA system TA122789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3279263..3279900
• Replicon: chromosome
• Accession: NZ_CP038437
• Organism: Halomonas sp. Y2R2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E4T21_RS14345
• Protein ID: WP_149285712.1
• Coordinates: 3279493..3279900 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E4T21_RS14340
• Protein ID: WP_149285711.1
• Coordinates: 3279263..3279493 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4T21_RS14325	3274877..3275800	+	924	WP_149285709.1	LysR family transcriptional regulator	-
E4T21_RS14330	3275967..3276860	+	894	WP_149285710.1	DMT family transporter	-
E4T21_RS14335	3277357..3279057	+	1701	WP_149287234.1	BCCT family transporter	-
E4T21_RS14340	3279263..3279493	+	231	WP_149285711.1	antitoxin	Antitoxin
E4T21_RS14345	3279493..3279900	+	408	WP_149285712.1	tRNA(fMet)-specific endonuclease VapC	Toxin
E4T21_RS14350	3280043..3280666	+	624	WP_149285713.1	TetR/AcrR family transcriptional regulator	-
E4T21_RS14355	3280681..3281493	-	813	WP_187775004.1	NAD(P)-binding domain-containing protein	-
E4T21_RS14360	3281707..3283773	+	2067	WP_149285715.1	NADH:flavin oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15225.65 Da
• Isoelectric Point: 7.8242

>T122789 WP_149285712.1 NZ_CP038437:3279493-3279900 [Halomonas sp. Y2R2]
MIKYMLDTNICIYTIKNKPPQVREVFKRHHEQLCMSSVTLMELIYGAEKSANPERNLHVIEGFAARLEVLPFNNDAAAHT
GQLRAELAKAGTPIGPYDQMIAGHARSMGLVVVTNNVREFQRVPGLRIEDWSMTC

Nucleotide

• Length: 408 bp

>T122789 NZ_CP038437:3279493-3279900 [Halomonas sp. Y2R2]
ATGATCAAATATATGCTCGATACCAACATCTGTATCTATACCATCAAGAACAAGCCGCCTCAGGTGCGTGAAGTGTTCAA
GCGACATCATGAGCAACTGTGCATGAGTAGTGTGACGCTCATGGAGCTGATCTACGGAGCGGAGAAATCGGCTAACCCCG
AGCGCAACCTGCACGTGATCGAAGGGTTCGCTGCTCGACTCGAGGTTTTGCCATTCAACAATGATGCAGCAGCCCATACC
GGCCAACTCAGAGCCGAACTGGCCAAGGCGGGTACACCGATTGGCCCGTATGACCAGATGATTGCTGGCCATGCTCGCTC
AATGGGCTTGGTGGTAGTCACCAACAACGTTCGTGAGTTTCAACGCGTCCCTGGCCTGCGCATTGAAGATTGGTCCATGA
CCTGCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8532.52 Da
• Isoelectric Point: 4.2821

>AT122789 WP_149285711.1 NZ_CP038437:3279263-3279493 [Halomonas sp. Y2R2]
MVQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRTRIITPAGEAWDSWFDEEGVTTDFMGERDQPLEQERETL

Nucleotide

• Length: 231 bp

>AT122789 NZ_CP038437:3279263-3279493 [Halomonas sp. Y2R2]
ATGGTCCAAGGATCCGTATTTCAGTCCAACCGTAGTCAGGCAGTGCGCCTGCCCAAGGCAGTTGCCCTGCCTGATGATGT
CAAACGAGTTGATGTGGTTGCTGTTGGCAGGACGCGAATCATCACGCCTGCGGGTGAGGCGTGGGATAGCTGGTTTGATG
AAGAAGGTGTCACCACAGACTTCATGGGCGAACGCGACCAGCCGCTTGAGCAGGAACGTGAGACTCTCTGA