Detailed information of TA system TA122788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2225768..2226270
• Replicon: chromosome
• Accession: NZ_CP038437
• Organism: Halomonas sp. Y2R2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4T21_RS09795
• Protein ID: WP_149284818.1
• Coordinates: 2225768..2226022 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: E4T21_RS09800
• Protein ID: WP_149284819.1
• Coordinates: 2226019..2226270 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4T21_RS09780	2222235..2223335	-	1101	WP_187775143.1	redoxin family protein	-
E4T21_RS09785	2223530..2224957	+	1428	WP_149284816.1	PLP-dependent aminotransferase family protein	-
E4T21_RS09790	2224995..2225531	+	537	WP_149284817.1	GNAT family N-acetyltransferase	-
E4T21_RS09795	2225768..2226022	-	255	WP_149284818.1	Txe/YoeB family addiction module toxin	Toxin
E4T21_RS09800	2226019..2226270	-	252	WP_149284819.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
E4T21_RS09805	2226597..2227937	-	1341	WP_205423487.1	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	-
E4T21_RS09810	2228211..2229623	+	1413	WP_149284821.1	APC family permease	-
E4T21_RS09815	2229738..2231192	+	1455	WP_149284822.1	benzaldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10093.50 Da
• Isoelectric Point: 8.8235

>T122788 WP_149284818.1 NZ_CP038437:c2226022-2225768 [Halomonas sp. Y2R2]
VKIVFSDQSWEDYLYWQGTNKKVLKRVNELVKAIKRDPFEGIGKPEPLKHHLTGTWSRRIDNEHRLVYEVEGESLYIVSC
RYHY

Nucleotide

• Length: 255 bp

>T122788 NZ_CP038437:c2226022-2225768 [Halomonas sp. Y2R2]
GTGAAGATCGTATTCTCTGATCAGTCCTGGGAAGACTATCTATACTGGCAAGGCACAAACAAGAAGGTTCTTAAGCGAGT
CAACGAGTTAGTGAAAGCGATCAAGCGAGACCCTTTCGAGGGTATCGGGAAGCCGGAACCATTAAAACACCACTTGACGG
GAACGTGGTCCAGGCGAATCGATAACGAGCACAGACTTGTCTATGAAGTCGAAGGTGAGTCCCTATACATCGTGTCTTGT
CGGTACCATTACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9562.71 Da
• Isoelectric Point: 4.8481

>AT122788 WP_149284819.1 NZ_CP038437:c2226270-2226019 [Halomonas sp. Y2R2]
MRTITYSKARQNFSAVLDETVNDHAPTLITRQNGEPCVLISLEEYDALEETAYLLRSPNNAERLQQSLKQLREGKGRERE
LIE

Nucleotide

• Length: 252 bp

>AT122788 NZ_CP038437:c2226270-2226019 [Halomonas sp. Y2R2]
ATGAGAACCATAACTTATTCAAAAGCAAGACAAAATTTTTCTGCTGTGCTCGATGAGACAGTTAACGACCATGCACCGAC
GCTTATCACACGTCAGAATGGTGAGCCGTGTGTACTCATATCTCTCGAAGAATACGATGCTCTTGAAGAGACGGCGTATC
TGCTCAGGTCACCTAACAATGCGGAGCGTCTTCAGCAGTCCTTGAAGCAGCTGAGAGAGGGAAAAGGTAGAGAGAGGGAG
CTGATCGAGTGA