Detailed information of TA system TA122787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 206171..206831
• Replicon: chromosome
• Accession: NZ_CP038437
• Organism: Halomonas sp. Y2R2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E4T21_RS00975
• Protein ID: WP_149282715.1
• Coordinates: 206171..206353 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: E4T21_RS00980
• Protein ID: WP_149282717.1
• Coordinates: 206421..206831 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4T21_RS00960	201263..202249	+	987	WP_149282709.1	xanthine dehydrogenase family protein subunit M	-
E4T21_RS00965	202258..204522	+	2265	WP_149282711.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
E4T21_RS00970	204829..205887	+	1059	WP_149282713.1	acyltransferase	-
E4T21_RS00975	206171..206353	+	183	WP_149282715.1	type II toxin-antitoxin system HicA family toxin	Toxin
E4T21_RS00980	206421..206831	+	411	WP_149282717.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E4T21_RS00985	206942..209914	-	2973	WP_149282719.1	hypothetical protein	-
E4T21_RS00990	210029..211111	-	1083	WP_149282721.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6753.84 Da
• Isoelectric Point: 10.6643

>T122787 WP_149282715.1 NZ_CP038437:206171-206353 [Halomonas sp. Y2R2]
VKSKELIRELEMAGWELKRTNGSHHHFQHPDISGTITVPHPKPDLGKGLVHKIRKQAGIV

Nucleotide

• Length: 183 bp

>T122787 NZ_CP038437:206171-206353 [Halomonas sp. Y2R2]
GTGAAAAGCAAGGAACTGATCAGAGAGCTGGAAATGGCGGGTTGGGAGCTCAAGCGAACGAATGGTAGCCATCATCATTT
TCAGCATCCTGACATATCCGGCACCATTACGGTGCCACATCCAAAACCTGATTTGGGAAAGGGCTTGGTACACAAGATAA
GAAAACAGGCAGGCATAGTTTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14699.58 Da
• Isoelectric Point: 4.3392

>AT122787 WP_149282717.1 NZ_CP038437:206421-206831 [Halomonas sp. Y2R2]
MYYPIAIEPGDDTTAFGVVVPDIPGCFSAGDTFDAAIANAREAIEGHLECLAESGESIPTASSIGNHMKDPEYEGWIWAA
VEVDIAPYLGKSHKINVTLPELLIHRIDRLVELHPGYGSRSGFLATAALHELERPI

Nucleotide

• Length: 411 bp

>AT122787 NZ_CP038437:206421-206831 [Halomonas sp. Y2R2]
ATGTACTATCCAATTGCTATCGAGCCCGGCGACGACACTACCGCCTTTGGTGTTGTCGTGCCCGATATTCCCGGCTGTTT
TTCGGCTGGGGACACGTTCGATGCCGCTATTGCCAATGCACGAGAGGCTATCGAAGGGCATCTGGAATGTCTGGCTGAGA
GTGGCGAGTCGATTCCGACCGCCAGCTCAATCGGAAACCATATGAAAGACCCTGAATATGAAGGCTGGATCTGGGCTGCT
GTCGAGGTGGACATTGCCCCTTATCTGGGAAAGAGCCACAAGATCAATGTGACCTTGCCTGAATTGCTGATCCACAGAAT
TGATCGCCTGGTTGAGCTACACCCGGGCTATGGTAGTCGTTCGGGATTCCTTGCCACGGCGGCACTGCATGAACTCGAGC
GCCCCATATAA