Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4979311..4979906 Replicon chromosome
Accession NZ_CP038428
Organism Escherichia coli O157:H7 strain 611

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag E3149_RS24880 Protein ID WP_000239579.1
Coordinates 4979556..4979906 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag E3149_RS24875 Protein ID WP_001223210.1
Coordinates 4979311..4979562 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3149_RS24865 4974976..4978755 + 3780 WP_000060930.1 autotransporter assembly complex protein TamB -
E3149_RS24870 4978758..4979099 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
E3149_RS24875 4979311..4979562 + 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
E3149_RS24880 4979556..4979906 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
E3149_RS24885 4979986..4980516 - 531 WP_000055075.1 inorganic diphosphatase -
E3149_RS24890 4980826..4981782 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
E3149_RS24895 4981922..4983424 + 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
E3149_RS24900 4983438..4984460 + 1023 WP_001301928.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T122781 WP_000239579.1 NZ_CP038428:4979556-4979906 [Escherichia coli O157:H7]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T122781 NZ_CP038428:4979556-4979906 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT122781 WP_001223210.1 NZ_CP038428:4979311-4979562 [Escherichia coli O157:H7]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT122781 NZ_CP038428:4979311-4979562 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8


Antitoxin

Source ID Structure

References