122774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3982104..3982858 Replicon chromosome
Accession NZ_CP038428
Organism Escherichia coli O157:H7 strain 611

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag E3149_RS20245 Protein ID WP_001301452.1
Coordinates 3982373..3982858 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag E3149_RS20240 Protein ID WP_000801912.1
Coordinates 3982104..3982382 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3149_RS20235 3979332..3982037 + 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -
E3149_RS20240 3982104..3982382 + 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
E3149_RS20245 3982373..3982858 + 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
E3149_RS20250 3982908..3983936 - 1029 WP_000827117.1 RNA 3'-terminal phosphate cyclase -
E3149_RS20255 3983940..3985166 - 1227 WP_001105473.1 RNA-splicing ligase RtcB -
E3149_RS20260 3985354..3986952 + 1599 WP_001232889.1 DNA-binding transcriptional regulator RtcR -
E3149_RS20265 3986934..3987692 - 759 WP_001302007.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(45-143)

Antitoxin

(2-92)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T122774 WP_001301452.1 NZ_CP038428:3982373-3982858 [Escherichia coli O157:H7]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

>T122774 NZ_CP038428:3982373-3982858 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT122774 WP_000801912.1 NZ_CP038428:3982104-3982382 [Escherichia coli O157:H7]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp

>AT122774 NZ_CP038428:3982104-3982382 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References