Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 950847..951325 Replicon chromosome
Accession NZ_CP038428
Organism Escherichia coli O157:H7 strain 611

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E3149_RS04475 Protein ID WP_001303876.1
Coordinates 950847..951134 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E3149_RS04480 Protein ID WP_000536233.1
Coordinates 951134..951325 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3149_RS04445 945996..948467 - 2472 WP_000034474.1 exonuclease -
E3149_RS04450 948561..948752 - 192 WP_001098307.1 DUF1482 family protein -
E3149_RS04455 948749..948937 - 189 WP_000413705.1 cell division inhibition protein DicB -
E3149_RS04460 949511..949696 + 186 WP_001133046.1 hypothetical protein -
E3149_RS04465 949883..950272 - 390 WP_000394511.1 hypothetical protein -
E3149_RS04470 950414..950569 - 156 WP_000379575.1 DUF1391 family protein -
E3149_RS04475 950847..951134 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3149_RS04480 951134..951325 - 192 WP_000536233.1 hypothetical protein Antitoxin
E3149_RS04485 951353..951754 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E3149_RS04490 951863..952135 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E3149_RS04495 952119..952544 + 426 WP_000693855.1 Rha family transcriptional regulator -
E3149_RS04500 952751..953206 - 456 WP_000273724.1 hypothetical protein -
E3149_RS04505 953285..954376 + 1092 WP_001205823.1 hypothetical protein -
E3149_RS04510 954383..955129 + 747 WP_000788751.1 ATP-binding protein -
E3149_RS04515 955151..955921 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T122755 WP_001303876.1 NZ_CP038428:c951134-950847 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T122755 NZ_CP038428:c951134-950847 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT122755 WP_000536233.1 NZ_CP038428:c951325-951134 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT122755 NZ_CP038428:c951325-951134 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References