Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3587138..3587973 Replicon chromosome
Accession NZ_CP038421
Organism Escherichia coli O157:H7 strain 7636

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag E3152_RS18320 Protein ID WP_032107687.1
Coordinates 3587138..3587515 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag E3152_RS18325 Protein ID WP_033805992.1
Coordinates 3587605..3587973 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3152_RS18290 3583819..3584523 + 705 WP_171881826.1 leucyl/phenylalanyl-tRNA--protein transferase -
E3152_RS18295 3584808..3585026 + 219 WP_001040187.1 translation initiation factor IF-1 -
E3152_RS18305 3585517..3586359 - 843 WP_001684189.1 DUF4942 domain-containing protein -
E3152_RS18310 3586465..3586641 - 177 WP_001684188.1 DUF957 domain-containing protein -
E3152_RS18315 3586653..3587141 - 489 WP_001684187.1 hypothetical protein -
E3152_RS18320 3587138..3587515 - 378 WP_032107687.1 type IV toxin-antitoxin system toxin CbtA Toxin
E3152_RS18325 3587605..3587973 - 369 WP_033805992.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E3152_RS18330 3588053..3588274 - 222 WP_001684649.1 DUF987 domain-containing protein -
E3152_RS18335 3588343..3588819 - 477 WP_001186745.1 RadC family protein -
E3152_RS18340 3588835..3589314 - 480 WP_001684386.1 antirestriction protein -
E3152_RS18345 3589480..3589653 - 174 WP_001684385.1 hypothetical protein -
E3152_RS18350 3589653..3590471 - 819 WP_033805991.1 DUF945 domain-containing protein -
E3152_RS18355 3590561..3590784 - 224 Protein_3597 DUF905 family protein -
E3152_RS18360 3590882..3591295 - 414 WP_000789535.1 hypothetical protein -
E3152_RS18365 3591565..3592104 - 540 WP_001104020.1 DUF4339 domain-containing protein -
E3152_RS18370 3592229..3592686 - 458 Protein_3600 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13903.98 Da        Isoelectric Point: 7.7785

>T122671 WP_032107687.1 NZ_CP038421:c3587515-3587138 [Escherichia coli O157:H7]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTCSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGVKQ

Download         Length: 378 bp

>T122671 NZ_CP038421:c3587515-3587138 [Escherichia coli O157:H7]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCTGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGTGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13578.33 Da        Isoelectric Point: 6.7384

>AT122671 WP_033805992.1 NZ_CP038421:c3587973-3587605 [Escherichia coli O157:H7]
VSDTLHETNHPDGNNNSPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADVYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSKTKK

Download         Length: 369 bp

>AT122671 NZ_CP038421:c3587973-3587605 [Escherichia coli O157:H7]
GTGTCAGACACGCTCCATGAAACAAATCACCCCGACGGCAATAACAACAGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGTATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCAAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References