Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3474395..3474873 Replicon chromosome
Accession NZ_CP038421
Organism Escherichia coli O157:H7 strain 7636

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E3152_RS17825 Protein ID WP_001303876.1
Coordinates 3474586..3474873 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E3152_RS17820 Protein ID WP_000536233.1
Coordinates 3474395..3474586 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3152_RS17785 3469799..3470569 - 771 WP_000450992.1 DUF1627 domain-containing protein -
E3152_RS17790 3470591..3471337 - 747 WP_000788751.1 ATP-binding protein -
E3152_RS17795 3471344..3472435 - 1092 WP_001205823.1 hypothetical protein -
E3152_RS17800 3472514..3472969 + 456 WP_000273724.1 hypothetical protein -
E3152_RS17805 3473176..3473601 - 426 WP_000693855.1 Rha family transcriptional regulator -
E3152_RS17810 3473585..3473857 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E3152_RS17815 3473966..3474367 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E3152_RS17820 3474395..3474586 + 192 WP_000536233.1 hypothetical protein Antitoxin
E3152_RS17825 3474586..3474873 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3152_RS17830 3475151..3475306 + 156 WP_000379575.1 DUF1391 family protein -
E3152_RS17835 3475448..3475837 + 390 WP_000394511.1 hypothetical protein -
E3152_RS17840 3476024..3476209 - 186 WP_001133046.1 hypothetical protein -
E3152_RS17845 3476783..3476971 + 189 WP_000413705.1 cell division inhibition protein DicB -
E3152_RS17850 3476968..3477159 + 192 WP_001098307.1 DUF1482 family protein -
E3152_RS17855 3477253..3479724 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T122670 WP_001303876.1 NZ_CP038421:3474586-3474873 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T122670 NZ_CP038421:3474586-3474873 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT122670 WP_000536233.1 NZ_CP038421:3474395-3474586 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT122670 NZ_CP038421:3474395-3474586 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References