Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3537755..3538233 Replicon chromosome
Accession NZ_CP038419
Organism Escherichia coli O157:H7 strain 2-6-2

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E4U89_RS18245 Protein ID WP_001303876.1
Coordinates 3537946..3538233 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E4U89_RS18240 Protein ID WP_000536233.1
Coordinates 3537755..3537946 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U89_RS18205 3533159..3533929 - 771 WP_000450992.1 DUF1627 domain-containing protein -
E4U89_RS18210 3533951..3534697 - 747 WP_000788751.1 ATP-binding protein -
E4U89_RS18215 3534704..3535795 - 1092 WP_001205823.1 hypothetical protein -
E4U89_RS18220 3535874..3536329 + 456 WP_000273724.1 hypothetical protein -
E4U89_RS18225 3536536..3536961 - 426 WP_000693855.1 Rha family transcriptional regulator -
E4U89_RS18230 3536945..3537217 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E4U89_RS18235 3537326..3537727 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E4U89_RS18240 3537755..3537946 + 192 WP_000536233.1 hypothetical protein Antitoxin
E4U89_RS18245 3537946..3538233 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4U89_RS18250 3538511..3538666 + 156 WP_000379575.1 DUF1391 family protein -
E4U89_RS18255 3538808..3539197 + 390 WP_000394511.1 hypothetical protein -
E4U89_RS18260 3539384..3539569 - 186 WP_001133046.1 hypothetical protein -
E4U89_RS18265 3540143..3540331 + 189 WP_000413705.1 cell division inhibition protein DicB -
E4U89_RS18270 3540328..3540519 + 192 WP_001098307.1 DUF1482 family protein -
E4U89_RS18275 3540613..3543084 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T122633 WP_001303876.1 NZ_CP038419:3537946-3538233 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T122633 NZ_CP038419:3537946-3538233 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT122633 WP_000536233.1 NZ_CP038419:3537755-3537946 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT122633 NZ_CP038419:3537755-3537946 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References