Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2976805..2977331 | Replicon | chromosome |
| Accession | NZ_CP038412 | ||
| Organism | Escherichia coli O157:H7 strain 493/89 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | E3172_RS14900 | Protein ID | WP_000323025.1 |
| Coordinates | 2976805..2977092 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | E3172_RS14905 | Protein ID | WP_000534858.1 |
| Coordinates | 2977092..2977331 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3172_RS14855 | 2971829..2972044 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| E3172_RS14860 | 2972798..2973013 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| E3172_RS14865 | 2973314..2973526 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| E3172_RS14870 | 2973581..2973670 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| E3172_RS14875 | 2973948..2974700 | - | 753 | WP_001047140.1 | antitermination protein | - |
| E3172_RS14880 | 2974714..2975763 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| E3172_RS14885 | 2975765..2976043 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| E3172_RS14890 | 2976110..2976361 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| E3172_RS14895 | 2976578..2976733 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| E3172_RS14900 | 2976805..2977092 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| E3172_RS14905 | 2977092..2977331 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| E3172_RS14910 | 2977356..2977661 | + | 306 | WP_071528610.1 | hypothetical protein | - |
| E3172_RS14915 | 2977864..2978196 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| E3172_RS14920 | 2978633..2979973 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| E3172_RS14925 | 2980007..2980426 | - | 420 | WP_001151196.1 | DUF977 family protein | - |
| E3172_RS14930 | 2980467..2981432 | - | 966 | WP_000054504.1 | hypothetical protein | - |
| E3172_RS14935 | 2981413..2981934 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| E3172_RS14940 | 2981918..2982145 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2941133..2989829 | 48696 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T122504 WP_000323025.1 NZ_CP038412:c2977092-2976805 [Escherichia coli O157:H7]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T122504 NZ_CP038412:c2977092-2976805 [Escherichia coli O157:H7]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT122504 WP_000534858.1 NZ_CP038412:c2977331-2977092 [Escherichia coli O157:H7]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT122504 NZ_CP038412:c2977331-2977092 [Escherichia coli O157:H7]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|