Detailed information of TA system
Overview
TA module
| Type | III | Classification (family/domain) | toxIN/ToxN(toxin) |
| Location | 1910..2678 | Replicon | plasmid pDEC4E-2 |
| Accession | NZ_CP038399 | ||
| Organism | Escherichia coli O157:H7 strain DEC4E | ||
Toxin (Protein)
| Gene name | toxN | Uniprot ID | - |
| Locus tag | E3154_RS26230 | Protein ID | WP_000675353.1 |
| Coordinates | 1910..2425 (-) | Length | 172 a.a. |
Antitoxin (RNA)
| Gene name | toxI | ||
| Locus tag | - | ||
| Coordinates | 2427..2678 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3154_RS26215 | 1..4634 | - | 4634 | WP_000786946.1 | hypothetical protein | - |
| E3154_RS26220 | 287..544 | - | 258 | WP_001125013.1 | hypothetical protein | - |
| E3154_RS26225 | 1089..1799 | + | 711 | WP_024165718.1 | hypothetical protein | - |
| E3154_RS26230 | 1910..2425 | - | 516 | WP_000675353.1 | type III toxin-antitoxin system ToxN/AbiQ family toxin | Toxin |
| - | 2427..2678 | - | 252 | NuclAT_0 | - | Antitoxin |
| - | 2427..2678 | - | 252 | NuclAT_0 | - | Antitoxin |
| - | 2427..2678 | - | 252 | NuclAT_0 | - | Antitoxin |
| - | 2427..2678 | - | 252 | NuclAT_0 | - | Antitoxin |
| - | 2477..2534 | - | 58 | NuclAT_9 | - | - |
| - | 2477..2534 | - | 58 | NuclAT_9 | - | - |
| - | 2477..2534 | - | 58 | NuclAT_9 | - | - |
| - | 2477..2534 | - | 58 | NuclAT_9 | - | - |
| - | 2477..2570 | - | 94 | NuclAT_7 | - | - |
| - | 2477..2570 | - | 94 | NuclAT_7 | - | - |
| - | 2477..2570 | - | 94 | NuclAT_7 | - | - |
| - | 2477..2570 | - | 94 | NuclAT_7 | - | - |
| - | 2477..2606 | - | 130 | NuclAT_5 | - | - |
| - | 2477..2606 | - | 130 | NuclAT_5 | - | - |
| - | 2477..2606 | - | 130 | NuclAT_5 | - | - |
| - | 2477..2606 | - | 130 | NuclAT_5 | - | - |
| - | 2477..2642 | - | 166 | NuclAT_3 | - | - |
| - | 2477..2642 | - | 166 | NuclAT_3 | - | - |
| - | 2477..2642 | - | 166 | NuclAT_3 | - | - |
| - | 2477..2642 | - | 166 | NuclAT_3 | - | - |
| E3154_RS26235 | 2480..2707 | - | 228 | WP_162775234.1 | hypothetical protein | - |
| - | 2513..2715 | - | 203 | NuclAT_1 | - | - |
| - | 2513..2715 | - | 203 | NuclAT_1 | - | - |
| - | 2513..2715 | - | 203 | NuclAT_1 | - | - |
| - | 2513..2715 | - | 203 | NuclAT_1 | - | - |
| - | 2549..2714 | - | 166 | NuclAT_2 | - | - |
| - | 2549..2714 | - | 166 | NuclAT_2 | - | - |
| - | 2549..2714 | - | 166 | NuclAT_2 | - | - |
| - | 2549..2714 | - | 166 | NuclAT_2 | - | - |
| - | 2585..2718 | - | 134 | NuclAT_4 | - | - |
| - | 2585..2718 | - | 134 | NuclAT_4 | - | - |
| - | 2585..2718 | - | 134 | NuclAT_4 | - | - |
| - | 2585..2718 | - | 134 | NuclAT_4 | - | - |
| - | 2621..2718 | - | 98 | NuclAT_6 | - | - |
| - | 2621..2718 | - | 98 | NuclAT_6 | - | - |
| - | 2621..2718 | - | 98 | NuclAT_6 | - | - |
| - | 2621..2718 | - | 98 | NuclAT_6 | - | - |
| - | 2657..2718 | - | 62 | NuclAT_8 | - | - |
| - | 2657..2718 | - | 62 | NuclAT_8 | - | - |
| - | 2657..2718 | - | 62 | NuclAT_8 | - | - |
| - | 2657..2718 | - | 62 | NuclAT_8 | - | - |
| E3154_RS26240 | 3595..3789 | - | 195 | WP_001041618.1 | Rop family plasmid primer RNA-binding protein | - |
| E3154_RS26245 | 4073..4396 | + | 324 | WP_000166966.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..4634 | 4634 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19763.71 Da Isoelectric Point: 5.6847
>T122382 WP_000675353.1 NZ_CP038399:c2425-1910 [Escherichia coli O157:H7]
MKFYTISSSYIKYLKDFDDKVPNSEDPTYNNPKAFIGIVLEIEGHKYLAPLTSPKAWHANVKESSPAFFKLHENGVPDNQ
LGLINLKFMIPIIEAEVSLLDLDSMPDTPYKRMLYKQLQFIRVNEDKISEKSKLLRNLALQGRMQGTCDFAVLEEKYQHF
GKKPEDMEIDD
MKFYTISSSYIKYLKDFDDKVPNSEDPTYNNPKAFIGIVLEIEGHKYLAPLTSPKAWHANVKESSPAFFKLHENGVPDNQ
LGLINLKFMIPIIEAEVSLLDLDSMPDTPYKRMLYKQLQFIRVNEDKISEKSKLLRNLALQGRMQGTCDFAVLEEKYQHF
GKKPEDMEIDD
Download Length: 516 bp
>T122382 NZ_CP038399:c2425-1910 [Escherichia coli O157:H7]
ATGAAATTTTACACAATATCAAGCAGTTACATAAAATACCTGAAGGACTTTGATGACAAAGTTCCCAATAGCGAAGATCC
TACATACAACAATCCTAAGGCTTTCATTGGCATAGTACTAGAGATTGAAGGACATAAATATTTAGCACCTTTAACGTCGC
CAAAAGCATGGCATGCTAATGTAAAAGAGTCATCACCCGCCTTCTTCAAACTTCATGAAAACGGTGTCCCTGACAATCAG
CTTGGATTGATTAATCTGAAATTTATGATTCCAATAATCGAAGCTGAAGTGTCTTTACTTGATCTGGATAGCATGCCTGA
TACGCCTTACAAAAGAATGCTATATAAACAGTTACAATTTATTCGTGTAAATGAAGATAAAATATCTGAAAAATCAAAAC
TATTAAGAAACCTTGCCTTGCAAGGCAGAATGCAAGGAACATGCGACTTTGCCGTATTAGAAGAAAAATATCAACATTTC
GGTAAAAAACCTGAAGACATGGAAATAGACGATTAA
ATGAAATTTTACACAATATCAAGCAGTTACATAAAATACCTGAAGGACTTTGATGACAAAGTTCCCAATAGCGAAGATCC
TACATACAACAATCCTAAGGCTTTCATTGGCATAGTACTAGAGATTGAAGGACATAAATATTTAGCACCTTTAACGTCGC
CAAAAGCATGGCATGCTAATGTAAAAGAGTCATCACCCGCCTTCTTCAAACTTCATGAAAACGGTGTCCCTGACAATCAG
CTTGGATTGATTAATCTGAAATTTATGATTCCAATAATCGAAGCTGAAGTGTCTTTACTTGATCTGGATAGCATGCCTGA
TACGCCTTACAAAAGAATGCTATATAAACAGTTACAATTTATTCGTGTAAATGAAGATAAAATATCTGAAAAATCAAAAC
TATTAAGAAACCTTGCCTTGCAAGGCAGAATGCAAGGAACATGCGACTTTGCCGTATTAGAAGAAAAATATCAACATTTC
GGTAAAAAACCTGAAGACATGGAAATAGACGATTAA
Antitoxin
Download Length: 252 bp
>AT122382 NZ_CP038399:c2678-2427 [Escherichia coli O157:H7]
AGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATT
TGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCT
TTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCTTAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTTT
TTACGAGAAAAA
AGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATT
TGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCT
TTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCTTAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTTT
TTACGAGAAAAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
