Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2500551..2501022 | Replicon | chromosome |
| Accession | NZ_CP038398 | ||
| Organism | Escherichia coli O157:H7 strain DEC4E | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | E3154_RS12375 | Protein ID | WP_001303511.1 |
| Coordinates | 2500551..2500829 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | E3154_RS12380 | Protein ID | WP_001302048.1 |
| Coordinates | 2500831..2501022 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3154_RS12335 | 2495557..2495741 | - | 185 | Protein_2414 | DUF3596 domain-containing protein | - |
| E3154_RS12340 | 2495776..2496027 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| E3154_RS12345 | 2496100..2498571 | - | 2472 | WP_000048458.1 | exonuclease | - |
| E3154_RS12350 | 2498664..2498855 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| E3154_RS12355 | 2498852..2499040 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| E3154_RS12360 | 2499441..2499605 | + | 165 | WP_001331716.1 | hypothetical protein | - |
| E3154_RS12365 | 2499609..2499827 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| E3154_RS12370 | 2499899..2500198 | - | 300 | WP_072143447.1 | hypothetical protein | - |
| E3154_RS12375 | 2500551..2500829 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| E3154_RS12380 | 2500831..2501022 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| E3154_RS12385 | 2501043..2501414 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| E3154_RS12390 | 2501512..2501814 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| E3154_RS12395 | 2501811..2502236 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| E3154_RS12400 | 2502259..2503221 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| E3154_RS12405 | 2503228..2503968 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| E3154_RS12410 | 2503994..2504173 | + | 180 | WP_001304151.1 | hypothetical protein | - |
| E3154_RS12415 | 2504248..2504762 | + | 515 | Protein_2430 | DUF1627 domain-containing protein | - |
| E3154_RS12420 | 2504778..2505173 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| E3154_RS12425 | 2505230..2505814 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2485671..2575449 | 89778 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T122365 WP_001303511.1 NZ_CP038398:c2500829-2500551 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T122365 NZ_CP038398:c2500829-2500551 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT122365 WP_001302048.1 NZ_CP038398:c2501022-2500831 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT122365 NZ_CP038398:c2501022-2500831 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|