Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 50759..51294 Replicon plasmid pDEC5B-4
Accession NZ_CP038392
Organism Escherichia coli O157:H7 strain DEC5B

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E3156_RS26165 Protein ID WP_000222786.1
Coordinates 51007..51294 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E3156_RS26160 Protein ID WP_001120171.1
Coordinates 50759..51010 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3156_RS26135 46956..47279 - 324 WP_000143875.1 hypothetical protein -
E3156_RS26140 47276..47713 - 438 WP_000843285.1 hypothetical protein -
E3156_RS26145 47713..48744 - 1032 WP_001085425.1 ParB/RepB/Spo0J family partition protein -
E3156_RS26150 48744..49610 - 867 WP_000172786.1 AAA family ATPase -
E3156_RS26155 49996..50535 - 540 WP_001218555.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
E3156_RS26160 50759..51010 + 252 WP_001120171.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3156_RS26165 51007..51294 + 288 WP_000222786.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3156_RS26170 51457..51654 - 198 WP_077631139.1 AraC family transcriptional regulator -
E3156_RS26175 51750..52897 + 1148 WP_085949497.1 IS3 family transposase -
E3156_RS26180 52917..53333 + 417 Protein_75 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - espT / espC 1..75328 75328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11130.06 Da        Isoelectric Point: 10.5077

>T122316 WP_000222786.1 NZ_CP038392:51007-51294 [Escherichia coli O157:H7]
MTYTVRFREDALKEWQKLDKAIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLVIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T122316 NZ_CP038392:51007-51294 [Escherichia coli O157:H7]
ATGACTTACACAGTCAGATTCAGGGAAGATGCACTGAAAGAATGGCAAAAACTGGATAAGGCAATTCAGCAGCAGTTTGC
TAAAAAGCTAAAGAAGTGCAGTGAAAATCCACATATCCCATCAGCAAAACTGCGTGGGATAAAGGATTGCTACAAAATTA
AACTTCGTGCGTCTGGCTTCCGCCTGGTTTATCAGGTGATTGATGATCAATTAGTTATCGCTGTTGTTGCTGTAGGGAAA
CGTGAACGTAGTGATGTTTATAATCTTGCCAGCGAACGAATGAGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9193.40 Da        Isoelectric Point: 4.2101

>AT122316 WP_001120171.1 NZ_CP038392:50759-51010 [Escherichia coli O157:H7]
MPHIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYEKMLDALDDQELVNLVAERSNQKLHDVDLD
SYL

Download         Length: 252 bp

>AT122316 NZ_CP038392:50759-51010 [Escherichia coli O157:H7]
ATGCCCCACATTATTCTGAGTGACACTAGCGCCAGTGTCAGCGAACTGAAAAAAAACCCGATGGCGACAGTCAGTGCCGG
TGATGGTTACCCAGTCGCGATTCTGAACCGTAACCAGCCCGCCTTTTACTGTGTCCCCGCAGAACTGTATGAAAAGATGC
TCGATGCCCTAGACGATCAGGAACTGGTTAATCTGGTCGCCGAACGCAGCAACCAGAAGCTGCACGATGTAGATCTGGAT
AGCTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References