Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1972364..1972842 Replicon chromosome
Accession NZ_CP038376
Organism Escherichia coli O157:H7 strain F1273

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E3159_RS09235 Protein ID WP_001303876.1
Coordinates 1972364..1972651 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E3159_RS09240 Protein ID WP_000536233.1
Coordinates 1972651..1972842 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3159_RS09205 1967513..1969984 - 2472 WP_000034474.1 exonuclease -
E3159_RS09210 1970078..1970269 - 192 WP_001098307.1 DUF1482 family protein -
E3159_RS09215 1970266..1970454 - 189 WP_000413705.1 cell division inhibition protein DicB -
E3159_RS09220 1971028..1971213 + 186 WP_001133046.1 hypothetical protein -
E3159_RS09225 1971400..1971789 - 390 WP_000394511.1 hypothetical protein -
E3159_RS09230 1971931..1972086 - 156 WP_000379575.1 DUF1391 family protein -
E3159_RS09235 1972364..1972651 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3159_RS09240 1972651..1972842 - 192 WP_000536233.1 hypothetical protein Antitoxin
E3159_RS09245 1972870..1973271 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E3159_RS09250 1973380..1973652 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E3159_RS09255 1973636..1974061 + 426 WP_000693855.1 Rha family transcriptional regulator -
E3159_RS09260 1974268..1974723 - 456 WP_000273724.1 hypothetical protein -
E3159_RS09265 1974802..1975893 + 1092 WP_128484534.1 DNA-binding protein -
E3159_RS09270 1975900..1976646 + 747 WP_000788751.1 ATP-binding protein -
E3159_RS09275 1976668..1977438 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T122157 WP_001303876.1 NZ_CP038376:c1972651-1972364 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T122157 NZ_CP038376:c1972651-1972364 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT122157 WP_000536233.1 NZ_CP038376:c1972842-1972651 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT122157 NZ_CP038376:c1972842-1972651 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References